Tbio PTGES3 Prostaglandin E synthase 3

Protein Summary

Description

Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q15185
• A8K7D0
• B4DHP2
• B4DP11
• B4DP21
• Q8WU70

Gene Name

• PTGES3

Ensembl ID

• ENST00000262033
• ENSP00000262033
• ENSG00000110958
• ENST00000414274
• ENSP00000405299
• ENST00000436399
• ENSP00000402385
• ENST00000448157
• ENSP00000414892

Symbol

• P23
• TEBP
• P23
• TEBP
• cPGES

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
disease perturbation	1
kinase perturbation	0.99
ligand (protein) perturbation	0.99
interacting protein	0.96

Protein Classes

PANTHER Classes

Protein / Chaperone / Prostaglandin E Synthase 3

DTO Classes

Protein / Chaperone / Prostaglandin E Synthase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.93   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 649   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.93   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 649   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0