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Tbio
PTGES3
Prostaglandin E synthase 3

Protein Classes
Protein Summary
Description
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262033
  • ENSP00000262033
  • ENSG00000110958
  • ENST00000414274
  • ENSP00000405299
  • ENST00000436399
  • ENSP00000402385
  • ENST00000448157
  • ENSP00000414892

Symbol
  • P23
  • TEBP
  • P23
  • TEBP
  • cPGES
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
kinase perturbation
0.99
ligand (protein) perturbation
0.99
interacting protein
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.18   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 649   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.18   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 649   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
65.2
reticulocyte count
3
2
3
47.9
sex hormone-binding globulin measurement
1
1
1
42.7
diastolic blood pressure
1
1
1
9.3
mean platelet volume
1
1
1
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
65.2
reticulocyte count
3
47.9
sex hormone-binding globulin measurement
1
42.7
diastolic blood pressure
1
9.3
mean platelet volume
1
3.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E synthase 3
VGNC:5550
746021
Macaque
prostaglandin E synthase 3
713353
Mouse
MGI:1929282
56351
Rat
RGD:1561913
362809
Horse
prostaglandin E synthase 3
VGNC:21992
100059858
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prostaglandin E synthase 3
Macaque
prostaglandin E synthase 3
Mouse
Rat
Horse
prostaglandin E synthase 3
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Aryl hydrocarbon receptor signalling
Reactome
Attenuation phase
Reactome
Biological oxidations
Reactome
Cellular response to heat stress
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Aryl hydrocarbon receptor signalling
Attenuation phase
Biological oxidations
Cellular response to heat stress
Gene Ontology Terms (28)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (277)
1 – 10 of 277
ANKMY2
Tdark
Novelty: 0.50777631
p_int: 0.996647055
p_ni: 0.003352945
Score: 0.39
Data Source: BioPlex,STRINGDB
AGO1
Tbio
Novelty: 0.00157424
p_int: 0.77845885
p_ni: 0.22154115
Data Source: BioPlex
HSP90AA1
Tchem
Novelty: 0.00016774
Score: 0.999
Data Source: Reactome,STRINGDB
STIP1
Tbio
Novelty: 0.00590952
Score: 0.998
Data Source: Reactome,STRINGDB
HSP90AB1
Tchem
Novelty: 0.00907961
Score: 0.996
Data Source: Reactome,STRINGDB
PPID
Tchem
Family: Enzyme
Novelty: 0.01068886
Score: 0.991
Data Source: Reactome,STRINGDB
CDC37
Tbio
Novelty: 0.03730196
Score: 0.986
Data Source: STRINGDB
VCP
Tchem
Family: Enzyme
Novelty: 0.00103317
Score: 0.983
Data Source: STRINGDB
PTGES2
Tchem
Family: Enzyme
Novelty: 0.01415352
Score: 0.982
Data Source: STRINGDB
FKBP4
Tchem
Family: Enzyme
Novelty: 0.0023525
Score: 0.982
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  83.18

PubMed score by year
PubTator Score  303.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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