Tbio PPA1 Inorganic pyrophosphatase

Protein Summary

Description

The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15181
• Q2M348
• Q5SQT7
• Q6P7P4
• Q9UQJ5
• Q9Y5B1

Gene Name

• PPA1

Ensembl ID

• ENST00000373232
• ENSP00000362329
• ENSG00000180817

Symbol

• IOPPP
• PP
• PP
• PP1
• IOPPP
• HEL-S-66p
• SID6-8061

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
virus perturbation	1
disease perturbation	0.98
interacting protein	0.94
transcription factor binding site profile	0.8

Protein Classes

PANTHER Classes

Protein / Hydrolase / Pyrophosphatase / Inorganic Pyrophosphatase

DTO Classes

Protein / Enzyme / Hydrolase / Pyrophosphatase / Inorganic Pyrophosphatase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1062.13   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 238   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1062.13   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0