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Tbio
PPA1
Inorganic pyrophosphatase

Protein Summary
Description
The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373232
  • ENSP00000362329
  • ENSG00000180817

Symbol
  • IOPPP
  • PP
  • PP
  • PP1
  • IOPPP
  • HEL-S-66p
  • SID6-8061
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
virus perturbation
1
disease perturbation
0.98
interacting protein
0.94
transcription factor binding site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 950.32   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 950.32   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (176)
1 – 10 of 176
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
Score:  0.964
Data Source:  STRINGDB
ATP4A
Tclin
Family:  Transporter
Novelty:  0.00008783
Score:  0.964
Data Source:  STRINGDB
ATP4B
Tclin
Family:  Transporter
Novelty:  0.06924436
Score:  0.915
Data Source:  STRINGDB
LHPP
Tbio
Family:  Enzyme
Novelty:  0.0356879
Score:  0.903
Data Source:  STRINGDB
ATP5F1A
Tbio
Family:  Enzyme
Novelty:  0.01052213
Score:  0.842
Data Source:  STRINGDB
ATP5PF
Tbio
Family:  Enzyme
Novelty:  0.00585408
Score:  0.836
Data Source:  STRINGDB
PPA2
Tbio
Family:  Enzyme
Novelty:  0.01790138
Score:  0.813
Data Source:  STRINGDB
ATP6V0B
Tbio
Family:  Enzyme
Novelty:  0.06595421
Score:  0.808
Data Source:  STRINGDB
MPRIP
Tbio
Family:  Enzyme
Novelty:  0.03253403
Score:  0.804
Data Source:  STRINGDB
ATP5PB
Tbio
Family:  Enzyme
Novelty:  0.07345384
Score:  0.789
Data Source:  STRINGDB
Pathways (7)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism
Reactome
Metabolism of proteins
Reactome
Pyrophosphate hydrolysis
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism
Metabolism of proteins
Pyrophosphate hydrolysis
Translation
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
38.8
IGF-1 measurement
1
1
1
35
comparative body size at age 10, self-reported
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
38.8
IGF-1 measurement
1
35
comparative body size at age 10, self-reported
1
17.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyrophosphatase (inorganic) 1
748973
Macaque
pyrophosphatase (inorganic) 1
716720
Mouse
MGI:97831
67895
Dog
pyrophosphatase (inorganic) 1
479238
Horse
pyrophosphatase (inorganic) 1
100072720
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyrophosphatase (inorganic) 1
Macaque
pyrophosphatase (inorganic) 1
Mouse
Dog
pyrophosphatase (inorganic) 1
Horse
pyrophosphatase (inorganic) 1
Publication Statistics
PubMed Score 950.32
PubMed score by year
PubTator Score 821.90
PubTator score by year