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Tbio
PPP2R5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

Protein Summary
Description
As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000164133
  • ENSP00000164133
  • ENSG00000068971

Symbol
  • B56B
  • PR61B
  • B56beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.89
transcription factor binding site profile
0.8
histone modification site profile
0.73
virus perturbation
0.72
kinase perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.05   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.05   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B'beta
VGNC:10400
451305
Mouse
MGI:2388480
225849
Rat
RGD:727786
309179
Dog
protein phosphatase 2 regulatory subunit B'beta
VGNC:44914
483755
Horse
protein phosphatase 2 regulatory subunit B'beta
VGNC:21781
100050735
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B'beta
Mouse
Rat
Dog
protein phosphatase 2 regulatory subunit B'beta
Horse
protein phosphatase 2 regulatory subunit B'beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15173-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (91)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 60
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Reactome
Adaptive Immune System
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Adaptive Immune System
Protein-Protein Interactions (282)
1 – 10 of 282
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
p_int: 0.99999999
p_ni: 1e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00060035
p_int: 0.99999844
p_ni: 0.00000156
Data Source: BioPlex
WNT3A
Tchem
Novelty: 0.00119275
p_int: 0.999998331
p_ni: 5.2e-8
p_wrong: 0.000001617
Score: 0.928
Data Source: BioPlex,STRINGDB
C1orf21
Tdark
Novelty: 0.33595495
p_int: 0.999996583
p_ni: 0.000003416
p_wrong: 1e-9
Data Source: BioPlex
FAM43A
Tdark
Novelty: 1.17401589
p_int: 0.999557776
p_ni: 5.7e-8
p_wrong: 0.000442167
Score: 0.268
Data Source: BioPlex,STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
Score: 0.998
Data Source: STRINGDB
PPP2R1B
Tbio
Family: Enzyme
Novelty: 0.03936638
Score: 0.992
Data Source: STRINGDB
PPP2CB
Tbio
Family: Enzyme
Novelty: 0.0483178
Score: 0.983
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.971
Data Source: Reactome,STRINGDB
SGO1
Tbio
Novelty: 0.01115849
Score: 0.961
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.05

PubMed score by year
PubTator Score  9.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer