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Tbio
TCEAL1
Transcription elongation factor A protein-like 1

Protein Summary
Description
May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly. This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372624
  • ENSP00000361707
  • ENSG00000172465
  • ENST00000372625
  • ENSP00000361708
  • ENST00000372626
  • ENSP00000361709

Symbol
  • SIIR
  • p21
  • SIIR
  • WEX9
  • pp21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
virus perturbation
0.83
kinase perturbation
0.71
tissue sample
0.68
PubMedID
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.65   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.65   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0