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Tbio
PLCB4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4

Protein Summary
Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278655
  • ENSP00000278655
  • ENSG00000101333
  • ENST00000378473
  • ENSP00000367734
  • ENST00000378493
  • ENSP00000367754
  • ENST00000378501
  • ENSP00000367762
  • ENST00000414679
  • ENSP00000390616

Symbol
  • ARCND2
  • PI-PLC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
trait
0.97
transcription factor perturbation
0.97
metabolite
0.89
transcription factor
0.83


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.29   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.29   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (297)
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.968
Data Source:  Reactome,STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
Score:  0.967
Data Source:  STRINGDB
GNA11
Tchem
Novelty:  0.00128664
Score:  0.962
Data Source:  Reactome,STRINGDB
ITPR3
Tchem
Family:  IC
Novelty:  0.00154917
Score:  0.952
Data Source:  STRINGDB
CYSLTR2
Tchem
Family:  GPCR
Novelty:  0.00895224
Score:  0.951
Data Source:  STRINGDB
ITPR2
Tbio
Family:  IC
Novelty:  0.00619813
Score:  0.948
Data Source:  STRINGDB
ITPR1
Tchem
Family:  IC
Novelty:  0.00111834
Score:  0.948
Data Source:  STRINGDB
OPN4
Tbio
Family:  GPCR
Novelty:  0.00105995
Score:  0.937
Data Source:  STRINGDB
GRM1
Tchem
Family:  GPCR
Novelty:  0.00099764
Score:  0.936
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.936
Data Source:  STRINGDB
Nearest Tclin Targets (28)
Explore Nearest Tclin Targets
Pathways (89)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
G-protein mediated events
Reactome
GPCR downstream signalling
Reactome
Inositol phosphate metabolism
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
G alpha (q) signalling events
G-protein mediated events
GPCR downstream signalling
Inositol phosphate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107464
18798
Rat
RGD:3345
25031
Dog
phospholipase C beta 4
VGNC:44646
477160
Horse
phospholipase C beta 4
VGNC:21538
100051485
Cow
phospholipase C beta 4
VGNC:32983
281985
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phospholipase C beta 4
Horse
phospholipase C beta 4
Cow
phospholipase C beta 4
Publication Statistics
PubMed Score 61.29
PubMed score by year
PubTator Score 39.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title