PLCB4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Protein Summary
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
- ENST00000278655
- ENSP00000278655
- ENSG00000101333
- ENST00000378473
- ENSP00000367734
- ENST00000378493
- ENSP00000367754
- ENST00000378501
- ENSP00000367762
- ENST00000414679
- ENSP00000390616
- ARCND2
- PI-PLC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
trait | 0.97 | ||
transcription factor perturbation | 0.97 | ||
metabolite | 0.89 | ||
transcription factor | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 61.29 (req: < 5)
Gene RIFs: 23 (req: <= 3)
Antibodies: 32 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 61.29 (req: >= 5)
Gene RIFs: 23 (req: > 3)
Antibodies: 32 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0