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Tbio
PLCB4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4

Protein Summary
Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction. The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278655
  • ENSP00000278655
  • ENSG00000101333
  • ENST00000378473
  • ENSP00000367734
  • ENST00000378493
  • ENSP00000367754
  • ENST00000378501
  • ENSP00000367762
  • ENST00000414679
  • ENSP00000390616

Symbol
  • ARCND2
  • PI-PLC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
trait
0.97
transcription factor perturbation
0.97
metabolite
0.89
transcription factor
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.64   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.64   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (89)
G alpha (i) signalling events (R-HSA-418594)

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Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
G-protein mediated events
Reactome
GPCR downstream signalling
Reactome
Inositol phosphate metabolism
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
G alpha (q) signalling events
G-protein mediated events
GPCR downstream signalling
Inositol phosphate metabolism
Protein-Protein Interactions (297)
1 – 10 of 297
GNAQ
Tbio
Novelty: 0.00176666
Score: 0.968
Data Source: Reactome,STRINGDB
GNAI3
Tbio
Novelty: 0.03936457
Score: 0.967
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00156526
Score: 0.962
Data Source: Reactome,STRINGDB
ITPR3
Tchem
Family: IC
Novelty: 0.00274855
Score: 0.952
Data Source: STRINGDB
CYSLTR2
Tchem
Family: GPCR
Novelty: 0.00930645
Score: 0.951
Data Source: STRINGDB
ITPR2
Tbio
Family: IC
Novelty: 0.0094474
Score: 0.948
Data Source: STRINGDB
ITPR1
Tchem
Family: IC
Novelty: 0.00160922
Score: 0.948
Data Source: STRINGDB
OPN4
Tbio
Family: GPCR
Novelty: 0.00152001
Score: 0.937
Data Source: STRINGDB
GRM1
Tchem
Family: GPCR
Novelty: 0.0009002
Score: 0.936
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.12575547
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.64

PubMed score by year
PubTator Score  39.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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