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Tchem
PRKD1
Serine/threonine-protein kinase D1

Protein Summary
Description
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331968
  • ENSP00000333568
  • ENSG00000184304
  • ENST00000616995
  • ENSP00000482645

Symbol
  • PKD
  • PKD1
  • PRKCM
  • PKD
  • PKCM
  • CHDED
  • PRKCM
  • PKC-MU
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
kinase
1
protein domain
1
molecular function
0.96


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 843.78   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 873   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 843.78   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 873   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 61
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ingenol mebutate
Rendered image for ingenol mebutate
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
2
6
77.2
balding measurement
1
1
1
76.4
self reported educational attainment
3
3
3
75.2
comparative body size at age 10, self-reported
1
1
1
73
intelligence
4
5
3
6.1
63.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
77.2
balding measurement
1
76.4
self reported educational attainment
3
75.2
comparative body size at age 10, self-reported
1
73
intelligence
3
6.1
63.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase D1
VGNC:3353
452834
Macaque
protein kinase D1
716937
Mouse
MGI:99879
18760
Rat
RGD:620964
85421
Dog
protein kinase D1
VGNC:44986
609091
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase D1
Macaque
protein kinase D1
Mouse
Rat
Dog
protein kinase D1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15139-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Gene Ontology Terms (54)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CACAO
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (151)
1 – 10 of 151
FUCA1
Tchem
Family:  Enzyme
Novelty:  0.00961721
p_int:  0.999997161
p_ni:  5.66e-7
p_wrong:  0.000002273
Score:  0.45
Data Source:  BioPlex,STRINGDB
SIX2
Tbio
Family:  TF
Novelty:  0.01046481
p_int:  0.999996623
p_ni:  5.3e-8
p_wrong:  0.000003325
Score:  0.238
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.99997271
p_ni:  0.000027288
p_wrong:  2e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
ZNF777
Tdark
Family:  TF
Novelty:  1.20195224
p_int:  0.999929457
p_ni:  0.000070496
p_wrong:  4.6e-8
Data Source:  BioPlex
RACK1
Tbio
Novelty:  0.00200617
Score:  0.944
Data Source:  STRINGDB
PRRT2
Tbio
Novelty:  0.00442931
Score:  0.936
Data Source:  STRINGDB
IGF1R
Tclin
Family:  Kinase
Novelty:  0.00034532
Score:  0.933
Data Source:  STRINGDB
IGF1
Tbio
Novelty:  0.00003878
Score:  0.923
Data Source:  STRINGDB
SSH1
Tbio
Family:  Enzyme
Novelty:  0.02079383
Score:  0.915
Data Source:  STRINGDB
GRB2
Tchem
Novelty:  0.00091605
Score:  0.915
Data Source:  STRINGDB
Publication Statistics
PubMed Score  843.78

PubMed score by year
PubTator Score  488.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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