Protein Summary
This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
- ENST00000368467
- ENSP00000357452
- ENSG00000163344
- PMKI
- PMK
- PMKA
- PMKASE
- POROK1
- HUMPMKI
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor binding site profile | 0.93 | ||
molecular function | 0.88 | ||
histone modification site profile | 0.84 | ||
interacting protein | 0.78 | ||
transcription factor | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 212.6 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 207 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 212.6 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 207 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (63)
SLC25A35
Family: Transporter
Novelty: 1.19834062
p_int: 0.993486663
p_ni: 0.006502548
p_wrong: 0.000010789
Score: 0.252
Data Source: BioPlex,STRINGDB
SNRNP27
Novelty: 0.0175187
p_int: 0.992398082
p_ni: 0.007586556
p_wrong: 0.000015362
Data Source: BioPlex
FGB
Novelty: 0.00437751
p_int: 0.991253789
p_ni: 0.008745925
p_wrong: 2.86e-7
Data Source: BioPlex
ARL6IP6
Novelty: 0.36643453
p_int: 0.982253413
p_ni: 0.017691754
p_wrong: 0.000054832
Score: 0.186
Data Source: BioPlex,STRINGDB
SCNM1
Novelty: 0.19700548
p_int: 0.98154327
p_ni: 0.018294338
p_wrong: 0.000162392
Score: 0.226
Data Source: BioPlex,STRINGDB
GTF2E2
Novelty: 0.18033153
p_int: 0.93909502
p_ni: 0.045132691
p_wrong: 0.015772289
Data Source: BioPlex
ODAPH
Novelty: 0.20386223
p_int: 0.904488436
p_ni: 0.085449263
p_wrong: 0.010062301
Data Source: BioPlex
SLC25A32
Family: Transporter
Novelty: 0.06270404
p_int: 0.885402695
p_ni: 0.007556899
p_wrong: 0.107040407
Score: 0.186
Data Source: BioPlex,STRINGDB
SETD3
Family: Epigenetic
Novelty: 0.07150702
p_int: 0.802328889
p_ni: 0.192614579
p_wrong: 0.005056532
Score: 0.187
Data Source: BioPlex,STRINGDB
NPPA
Novelty: 0.00046693
p_int: 0.791972227
p_ni: 0.196194568
p_wrong: 0.011833206
Data Source: BioPlex
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (17)
Reactome (6)
KEGG (3)
PathwayCommons (5)
UniProt (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | Cholesterol biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of steroids | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of gene expression by SREBF (SREBP) | ||||
Cholesterol biosynthesis | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of steroids | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (4)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (32)
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
9 | 6 | 0 | 1.1 | 98.5 | |||||
BMI-adjusted waist-hip ratio | 9 | 7 | 18 | 96.8 | |||||
appendicular lean mass | 3 | 3 | 6 | 95.3 | |||||
eosinophil count | 3 | 2 | 3 | 93.2 | |||||
waist-hip ratio | 3 | 7 | 9 | 90.5 | |||||
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 98.5 | |||||
BMI-adjusted waist-hip ratio | 18 | 96.8 | |||||
appendicular lean mass | 6 | 95.3 | |||||
eosinophil count | 3 | 93.2 | |||||
waist-hip ratio | 9 | 90.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | phosphomevalonate kinase | VGNC:1461 | 457350 | |||||
Mouse | MGI:1915853 | 68603 | ||||||
Rat | RGD:1310812 | 310645 | ||||||
Dog | phosphomevalonate kinase | VGNC:44739 | 612251 | |||||
Horse | phosphomevalonate kinase | VGNC:21619 | 100062963 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | phosphomevalonate kinase | |||||
Mouse | ||||||
Rat | ||||||
Dog | phosphomevalonate kinase | |||||
Horse | phosphomevalonate kinase | |||||
Publication Statistics
PubMed Score 212.60
PubMed score by year
PubTator Score 34.04
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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