Tbio PMVK Phosphomevalonate kinase

Protein Summary

Description

This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Uniprot Accession IDs

• Q15126
• Q5TZW9
• PMKase

Gene Name

• PMVK

Ensembl ID

• ENST00000368467
• ENSP00000357452
• ENSG00000163344

Symbol

• PMKI
• PMK
• PMKA
• PMKASE
• POROK1
• HUMPMKI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.93
molecular function	0.88
histone modification site profile	0.84
interacting protein	0.78
transcription factor	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.82   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 207   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.82   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0