You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PMVK
Phosphomevalonate kinase

Protein Summary
Description
This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368467
  • ENSP00000357452
  • ENSG00000163344

Symbol
  • PMKI
  • PMK
  • PMKA
  • PMKASE
  • POROK1
  • HUMPMKI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
molecular function
0.88
histone modification site profile
0.84
interacting protein
0.78
transcription factor
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.6   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.6   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (63)
SLC25A35
Tdark
Family:  Transporter
Novelty:  1.19834062
p_int:  0.993486663
p_ni:  0.006502548
p_wrong:  0.000010789
Score:  0.252
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.992398082
p_ni:  0.007586556
p_wrong:  0.000015362
Data Source:  BioPlex
FGB
Tbio
Novelty:  0.00437751
p_int:  0.991253789
p_ni:  0.008745925
p_wrong:  2.86e-7
Data Source:  BioPlex
ARL6IP6
Tdark
Novelty:  0.36643453
p_int:  0.982253413
p_ni:  0.017691754
p_wrong:  0.000054832
Score:  0.186
Data Source:  BioPlex,STRINGDB
SCNM1
Tbio
Novelty:  0.19700548
p_int:  0.98154327
p_ni:  0.018294338
p_wrong:  0.000162392
Score:  0.226
Data Source:  BioPlex,STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.93909502
p_ni:  0.045132691
p_wrong:  0.015772289
Data Source:  BioPlex
ODAPH
Tbio
Novelty:  0.20386223
p_int:  0.904488436
p_ni:  0.085449263
p_wrong:  0.010062301
Data Source:  BioPlex
SLC25A32
Tbio
Family:  Transporter
Novelty:  0.06270404
p_int:  0.885402695
p_ni:  0.007556899
p_wrong:  0.107040407
Score:  0.186
Data Source:  BioPlex,STRINGDB
SETD3
Tbio
Family:  Epigenetic
Novelty:  0.07150702
p_int:  0.802328889
p_ni:  0.192614579
p_wrong:  0.005056532
Score:  0.187
Data Source:  BioPlex,STRINGDB
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.791972227
p_ni:  0.196194568
p_wrong:  0.011833206
Data Source:  BioPlex
Pathways (17)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
6
0
1.1
98.5
BMI-adjusted waist-hip ratio
9
7
18
96.8
appendicular lean mass
3
3
6
95.3
eosinophil count
3
2
3
93.2
waist-hip ratio
3
7
9
90.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
98.5
BMI-adjusted waist-hip ratio
18
96.8
appendicular lean mass
6
95.3
eosinophil count
3
93.2
waist-hip ratio
9
90.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphomevalonate kinase
VGNC:1461
457350
Mouse
MGI:1915853
68603
Rat
RGD:1310812
310645
Dog
phosphomevalonate kinase
VGNC:44739
612251
Horse
phosphomevalonate kinase
VGNC:21619
100062963
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphomevalonate kinase
Mouse
Rat
Dog
phosphomevalonate kinase
Horse
phosphomevalonate kinase
Publication Statistics
PubMed Score 212.60
PubMed score by year
PubTator Score 34.04
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title