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Tchem
EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Protein Classes
Protein Summary
Description
Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000495186
  • ENSP00000417052
  • ENSG00000147155

Symbol
  • CPX
  • CHO2
  • CPXD
  • MEND
  • CDPX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.93
small molecule perturbation
0.92
histone modification site profile
0.91
transcription factor perturbation
0.88


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.07   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.07   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107822
13595
Rat
RGD:620957
117278
Horse
emopamil binding protein (sterol isomerase)
100051672
Cow
emopamil binding protein (sterol isomerase)
515569
Opossum
emopamil binding protein (sterol isomerase)
100018802
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
emopamil binding protein (sterol isomerase)
Cow
emopamil binding protein (sterol isomerase)
Opossum
emopamil binding protein (sterol isomerase)
Pathways (13)
Cholesterol biosynthesis (R-HSA-191273)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cholesterol biosynthesis
Reactome
Cholesterol biosynthesis via desmosterol
Reactome
Cholesterol biosynthesis via lathosterol
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Cholesterol biosynthesis
Cholesterol biosynthesis via desmosterol
Cholesterol biosynthesis via lathosterol
Metabolism
Metabolism of lipids
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (69)
1 – 10 of 69
P2RY12
Tclin
Family: GPCR
Novelty: 0.00035406
p_int: 0.930218114
p_ni: 0.069683077
p_wrong: 0.000098809
Data Source: BioPlex
GPR21
Tdark
Family: GPCR
Novelty: 0.90865557
p_int: 0.929000944
p_ni: 0.070965665
p_wrong: 0.00003339
Data Source: BioPlex
FZD10
Tbio
Family: GPCR
Novelty: 0.02786933
p_int: 0.912785146
p_ni: 0.086607305
p_wrong: 0.000607549
Data Source: BioPlex
VIPR2
Tchem
Family: GPCR
Novelty: 0.00463802
p_int: 0.905145919
p_ni: 0.094376527
p_wrong: 0.000477555
Data Source: BioPlex
REEP5
Tbio
Novelty: 0.00160455
p_int: 0.885494327
p_ni: 0.113015032
p_wrong: 0.001490641
Data Source: BioPlex
GPR52
Tchem
Family: GPCR
Novelty: 0.07988639
p_int: 0.88177152
p_ni: 0.115418524
p_wrong: 0.002809956
Data Source: BioPlex
SLC6A15
Tchem
Family: Transporter
Novelty: 0.04011524
p_int: 0.877136299
p_ni: 0.122083684
p_wrong: 0.000780017
Data Source: BioPlex
HTR3A
Tclin
Family: IC
Novelty: 0.00217443
p_int: 0.871828276
p_ni: 0.122437147
p_wrong: 0.005734576
Data Source: BioPlex
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.864421026
p_ni: 0.133485813
p_wrong: 0.00209316
Data Source: BioPlex
EDNRA
Tclin
Family: GPCR
Novelty: 0.00045591
p_int: 0.861392487
p_ni: 0.137217551
p_wrong: 0.001389961
Score: 0.211
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  161.07

PubMed score by year
PubTator Score  602.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer