Tchem EBP 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

Protein Summary

Description

Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers. The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15125
• Q6FGL3
• Q6IBI9

Gene Name

• EBP

Ensembl ID

• ENST00000495186
• ENSP00000417052
• ENSG00000147155

Symbol

• CPX
• CHO2
• CPXD
• MEND
• CDPX2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
kinase perturbation	0.93
small molecule perturbation	0.92
histone modification site profile	0.91
transcription factor perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Isomerase / 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase

DTO Classes

Protein / Enzyme / Isomerase / 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.86   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 161   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.86   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10