Tbio PGM5 Phosphoglucomutase-like protein 5

Protein Summary

Description

Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity. Phosphoglucomutases (EC 5.2.2.2.), such as PGM5, are phosphotransferases involved in interconversion of glucose-1-phosphate and glucose-6-phosphate. PGM activity is essential in formation of carbohydrates from glucose-6-phosphate and in formation of glucose-6-phosphate from galactose and glycogen (Edwards et al., 1995 [PubMed 8586438]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q15124
• B1AM46
• B4DLQ6
• Q5VYV3
• Q8N527
• Q9UDH4

Gene Name

• PGM5

Ensembl ID

• ENST00000396392
• ENSP00000379674
• ENSG00000154330
• ENST00000396396
• ENSP00000379678

Symbol

• PGMRP
• PGMRP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
virus perturbation	0.9
cellular component	0.69
PubMedID	0.68
tissue sample	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.73   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 95   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.73   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0