You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PDK3
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial

Protein Classes
Protein Summary
Description
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. Th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379162
  • ENSP00000368460
  • ENSG00000067992
  • ENST00000441463
  • ENSP00000387536
  • ENST00000648777
  • ENSP00000497727

Symbol
  • PDHK3
  • CMTX6
  • GS1-358P8.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.99
transcription factor perturbation
0.99
disease perturbation
0.97
molecular function
0.93
histone modification site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.16   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.16   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3727577
chemical structure image
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
Regulation of pyruvate dehydrogenase (PDH) complex
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Regulation of pyruvate dehydrogenase (PDH) complex
Signal Transduction
Protein-Protein Interactions (52)
1 – 10 of 52
PDHA2
Tbio
Family: Enzyme
Novelty: 0.06763029
p_int: 1
Score: 0.947
Data Source: BioPlex,Reactome,STRINGDB
PDK1
Tchem
Family: Kinase
Novelty: 0.01117794
p_int: 1
Score: 0.839
Data Source: BioPlex,STRINGDB
PDK2
Tchem
Family: Kinase
Novelty: 0.01418114
p_int: 0.999999849
p_ni: 1.51e-7
Score: 0.869
Data Source: BioPlex,STRINGDB
PDHB
Tbio
Family: Enzyme
Novelty: 0.01625694
p_int: 0.999999846
p_ni: 1.54e-7
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
FOXD4
Tbio
Family: TF
Novelty: 0.15916764
p_int: 0.999992916
p_ni: 0.000007084
Score: 0.782
Data Source: BioPlex,STRINGDB
PDK4
Tchem
Family: Kinase
Novelty: 0.00549973
p_int: 0.999934625
p_ni: 0.000065375
Score: 0.831
Data Source: BioPlex,STRINGDB
PDHX
Tbio
Family: Enzyme
Novelty: 0.0031605
p_int: 0.999744824
p_ni: 0.000255176
Score: 0.991
Data Source: BioPlex,Reactome,STRINGDB
SYT12
Tbio
Novelty: 0.06785427
p_int: 0.999384651
p_ni: 0.000615349
Score: 0.288
Data Source: BioPlex,STRINGDB
PDHA1
Tbio
Family: Enzyme
Novelty: 0.00498626
p_int: 0.999277737
p_ni: 0.000722263
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
DLAT
Tbio
Family: Enzyme
Novelty: 0.00424045
p_int: 0.997679711
p_ni: 0.002320289
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  8.16

PubMed score by year
PubTator Score  20.81

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer