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Tchem
PDK3
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial

Protein Summary
Description
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. Th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379162
  • ENSP00000368460
  • ENSG00000067992
  • ENST00000441463
  • ENSP00000387536
  • ENST00000648777
  • ENSP00000497727

Symbol
  • PDHK3
  • CMTX6
  • GS1-358P8.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.99
transcription factor perturbation
0.99
disease perturbation
0.97
molecular function
0.93
histone modification site profile
0.78


Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.45   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.45   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehydrogenase kinase 3
VGNC:6436
740576
Macaque
pyruvate dehydrogenase kinase 3
699394
Mouse
MGI:2384308
236900
Rat
RGD:1593276
296849
Dog
pyruvate dehydrogenase kinase 3
VGNC:44382
480868
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehydrogenase kinase 3
Macaque
pyruvate dehydrogenase kinase 3
Mouse
Rat
Dog
pyruvate dehydrogenase kinase 3
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15120-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
Regulation of pyruvate dehydrogenase (PDH) complex
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Regulation of pyruvate dehydrogenase (PDH) complex
Signal Transduction
Protein-Protein Interactions (52)
1 – 10 of 52
PDHA2
Tbio
Family:  Enzyme
Novelty:  0.06188763
p_int:  1
Score:  0.947
Data Source:  BioPlex,Reactome,STRINGDB
PDK1
Tchem
Family:  Kinase
Novelty:  0.0078496
p_int:  1
Score:  0.839
Data Source:  BioPlex,STRINGDB
PDK2
Tchem
Family:  Kinase
Novelty:  0.01502257
p_int:  0.999999849
p_ni:  1.51e-7
Score:  0.869
Data Source:  BioPlex,STRINGDB
PDHB
Tbio
Family:  Enzyme
Novelty:  0.01018086
p_int:  0.999999846
p_ni:  1.54e-7
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
FOXD4
Tbio
Family:  TF
Novelty:  0.11166611
p_int:  0.999992916
p_ni:  0.000007084
Score:  0.782
Data Source:  BioPlex,STRINGDB
PDK4
Tchem
Family:  Kinase
Novelty:  0.00410067
p_int:  0.999934625
p_ni:  0.000065375
Score:  0.831
Data Source:  BioPlex,STRINGDB
PDHX
Tbio
Family:  Enzyme
Novelty:  0.00946631
p_int:  0.999744824
p_ni:  0.000255176
Score:  0.991
Data Source:  BioPlex,Reactome,STRINGDB
SYT12
Tbio
Novelty:  0.03410873
p_int:  0.999384651
p_ni:  0.000615349
Score:  0.288
Data Source:  BioPlex,STRINGDB
PDHA1
Tbio
Family:  Enzyme
Novelty:  0.00392231
p_int:  0.999277737
p_ni:  0.000722263
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
DLAT
Tbio
Family:  Enzyme
Novelty:  0.00311191
p_int:  0.997679711
p_ni:  0.002320289
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  22.45

PubMed score by year
PubTator Score  20.81

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer