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Tchem
PDK1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

Protein Summary
Description
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress. Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282077
  • ENSP00000282077
  • ENSG00000152256
  • ENST00000392571
  • ENSP00000376352
  • ENST00000410055
  • ENSP00000386985

Symbol
  • PDHK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
PubMedID
0.94
kinase perturbation
0.91
molecular function
0.91
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.06   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 636   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.06   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 636   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 102
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (173)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
Regulation of pyruvate dehydrogenase (PDH) complex
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Regulation of pyruvate dehydrogenase (PDH) complex
Signal Transduction
Protein-Protein Interactions (125)
1 – 10 of 125
PDK3
Tchem
Family: Kinase
Novelty: 0.05009442
p_int: 1
Score: 0.839
Data Source: BioPlex,STRINGDB
PDK2
Tchem
Family: Kinase
Novelty: 0.01502257
p_int: 0.999999962
p_ni: 3.8e-8
Score: 0.91
Data Source: BioPlex,STRINGDB
FOXD4
Tbio
Family: TF
Novelty: 0.11166611
p_int: 0.999998293
p_ni: 0.000001707
Score: 0.647
Data Source: BioPlex,STRINGDB
PDK4
Tchem
Family: Kinase
Novelty: 0.00410067
p_int: 0.999664796
p_ni: 0.000335204
Score: 0.828
Data Source: BioPlex,STRINGDB
CRBN
Tclin
Novelty: 0.00385433
p_int: 0.998900553
p_ni: 0.001077012
p_wrong: 0.000022435
Score: 0.234
Data Source: BioPlex,STRINGDB
NDUFS7
Tclin
Family: Enzyme
Novelty: 0.01562198
p_int: 0.987629181
p_ni: 0.01236723
p_wrong: 0.00000359
Data Source: BioPlex
ACAD9
Tbio
Family: Enzyme
Novelty: 0.03238308
p_int: 0.987560964
p_ni: 0.012438911
p_wrong: 1.25e-7
Score: 0.507
Data Source: BioPlex,STRINGDB
SLC18A1
Tchem
Family: Transporter
Novelty: 0.01135292
p_int: 0.982652996
p_ni: 0.017345208
p_wrong: 0.000001796
Data Source: BioPlex
PDHB
Tbio
Family: Enzyme
Novelty: 0.01018086
p_int: 0.982590067
p_ni: 0.017409933
Score: 0.988
Data Source: BioPlex,Reactome,STRINGDB
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.981154959
p_ni: 0.018845041
Data Source: BioPlex
Publication Statistics
PubMed Score  129.06

PubMed score by year
PubTator Score  421.82

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer