PDK1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.98 | ||
PubMedID | 0.94 | ||
kinase perturbation | 0.91 | ||
molecular function | 0.91 | ||
transcription factor binding site profile | 0.88 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Pyruvate metabolism | ||||
Reactome | Pyruvate metabolism and Citric Acid (TCA) cycle | ||||
Reactome | Regulation of pyruvate dehydrogenase (PDH) complex | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Metabolism | ||||
Pyruvate metabolism | ||||
Pyruvate metabolism and Citric Acid (TCA) cycle | ||||
Regulation of pyruvate dehydrogenase (PDH) complex | ||||
Signal Transduction | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
fasting blood glucose measurement | 1 | 1 | 1 | 46.1 | |||||
glucose measurement | 1 | 1 | 1 | 27.3 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
fasting blood glucose measurement | 1 | 46.1 | |||||
glucose measurement | 1 | 27.3 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | pyruvate dehydrogenase kinase 1 | VGNC:6370 | 459743 | |||||
Macaque | pyruvate dehydrogenase kinase 1 | 697772 | ||||||
Mouse | MGI:1926119 | 228026 | ||||||
Rat | RGD:69427 | 116551 | ||||||
Dog | pyruvate dehydrogenase kinase 1 | 476828 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | pyruvate dehydrogenase kinase 1 | |||||
Macaque | pyruvate dehydrogenase kinase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | pyruvate dehydrogenase kinase 1 | |||||
PMID | Year | Title |
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