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Tclin
PDCD1
Programmed cell death protein 1

Protein Summary
Description
Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors. This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334409
  • ENSP00000335062
  • ENSG00000188389
  • ENST00000618185
  • ENSP00000480684
  • ENSG00000276977

Symbol
  • PD1
  • PD1
  • PD-1
  • CD279
  • SLEB2
  • hPD-1
  • hPD-l
  • hSLE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
phenotype
0.83
disease
0.68
tissue sample
0.67
hub protein
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2596.92   (req: < 5)
Gene RIFs: 641   (req: <= 3)
Antibodies: 1947   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2596.92   (req: >= 5)
Gene RIFs: 641   (req: > 3)
Antibodies: 1947   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
programmed cell death 1
100135775
Mouse
MGI:104879
18566
Rat
RGD:1311658
301626
Dog
programmed cell death 1
VGNC:44334
486213
Horse
programmed cell death 1
VGNC:21226
100067948
Species
Name
OMA
EggNOG
Inparanoid
Macaque
programmed cell death 1
Mouse
Rat
Dog
programmed cell death 1
Horse
programmed cell death 1
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15116-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (290)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Immune System
Reactome
PD-1 signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Immune System
PD-1 signaling
Protein-Protein Interactions (200)
1 – 10 of 200
RAB5IF
Tdark
Novelty: 0.66468447
p_int: 0.999980455
p_ni: 0.000019543
p_wrong: 2e-9
Data Source: BioPlex
POP5
Tbio
Family: Enzyme
Novelty: 0.02459167
p_int: 0.999690875
p_ni: 0.000200356
p_wrong: 0.000108769
Data Source: BioPlex
SFXN3
Tbio
Novelty: 0.18698456
p_int: 0.999572917
p_ni: 0.000427081
p_wrong: 1e-9
Data Source: BioPlex
SLC25A23
Tbio
Family: Transporter
Novelty: 0.10446757
p_int: 0.998225092
p_ni: 0.001773106
p_wrong: 0.000001802
Data Source: BioPlex
DAGLB
Tchem
Family: Enzyme
Novelty: 0.03269024
p_int: 0.997329418
p_ni: 0.002669811
p_wrong: 7.7e-7
Data Source: BioPlex
SMDT1
Tbio
Novelty: 0.02448475
p_int: 0.996571355
p_ni: 0.000696629
p_wrong: 0.002732017
Data Source: BioPlex
RHBDF2
Tbio
Family: Enzyme
Novelty: 0.02487334
p_int: 0.995140042
p_ni: 0.004788006
p_wrong: 0.000071951
Score: 0.162
Data Source: BioPlex,STRINGDB
DENND6A
Tbio
Novelty: 4.5572617
p_int: 0.991856325
p_ni: 0.008141345
p_wrong: 0.000002331
Data Source: BioPlex
SLC25A28
Tbio
Family: Transporter
Novelty: 0.05050869
p_int: 0.99146815
p_ni: 0.000003625
p_wrong: 0.008528225
Score: 0.173
Data Source: BioPlex,STRINGDB
INTS4
Tdark
Novelty: 0.20868831
p_int: 0.991417692
p_ni: 0.008582308
Data Source: BioPlex
Publication Statistics
PubMed Score  2596.92

PubMed score by year
PubTator Score  1771.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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