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Tbio
PCOLCE
Procollagen C-endopeptidase enhancer 1

Protein Summary
Description
Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity. Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223061
  • ENSP00000223061
  • ENSG00000106333

Symbol
  • PCPE1
  • PCPE
  • PCPE1
  • PCPE-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
gene perturbation
0.85
disease perturbation
0.79
protein domain
0.73
disease
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.55   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.55   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
procollagen C-endopeptidase enhancer
VGNC:4459
463604
Macaque
procollagen C-endopeptidase enhancer
712496
Mouse
MGI:105099
18542
Rat
RGD:3270
29569
Dog
procollagen C-endopeptidase enhancer
VGNC:44316
489835
Species
Name
OMA
EggNOG
Inparanoid
Chimp
procollagen C-endopeptidase enhancer
Macaque
procollagen C-endopeptidase enhancer
Mouse
Rat
Dog
procollagen C-endopeptidase enhancer
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15113-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Assembly of collagen fibrils and other multimeric structures (R-HSA-2022090)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Crosslinking of collagen fibrils
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen formation
Crosslinking of collagen fibrils
Extracellular matrix organization
Protein-Protein Interactions (75)
1 – 10 of 75
COL3A1
Tbio
Novelty: 0.00197327
Score: 0.978
Data Source: STRINGDB
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.976
Data Source: STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.972
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.97
Data Source: STRINGDB
COL5A2
Tbio
Novelty: 0.01352973
Score: 0.95
Data Source: STRINGDB
COL2A1
Tbio
Novelty: 0.0011102
Score: 0.941
Data Source: STRINGDB
LOX
Tbio
Family: Enzyme
Novelty: 0.000273
Score: 0.941
Data Source: STRINGDB
LOXL1
Tbio
Family: Enzyme
Novelty: 0.00479897
Score: 0.939
Data Source: STRINGDB
LOXL2
Tbio
Family: Enzyme
Novelty: 0.00599536
Score: 0.926
Data Source: STRINGDB
COL11A1
Tbio
Novelty: 0.00594683
Score: 0.919
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.55

PubMed score by year
PubTator Score  45.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer