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Tbio
PLCL1
Inactive phospholipase C-like protein 1

Protein Summary
Description
Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000428675
  • ENSP00000402861
  • ENSG00000115896

Symbol
  • PLCE
  • PLCL
  • PRIP
  • PLDL1
  • PPP1R127
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
microRNA
0.82
disease
0.74
molecular function
0.73
tissue sample
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.52   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.52   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
GABRE
Tclin
Family:  IC
Novelty:  0.03814541
Score:  0.777
Data Source:  STRINGDB
NOL4
Tbio
Novelty:  0.04108058
Score:  0.679
Data Source:  STRINGDB
GABRG2
Tclin
Family:  IC
Novelty:  0.00819163
Score:  0.669
Data Source:  STRINGDB
GABRG1
Tclin
Family:  IC
Novelty:  0.04214561
Score:  0.63
Data Source:  STRINGDB
GABRB2
Tclin
Family:  IC
Novelty:  0.01954146
Score:  0.628
Data Source:  STRINGDB
GABRB1
Tclin
Family:  IC
Novelty:  0.02895574
Score:  0.624
Data Source:  STRINGDB
GABRD
Tclin
Family:  IC
Novelty:  0.0204242
Score:  0.622
Data Source:  STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
Score:  0.621
Data Source:  STRINGDB
GABRA4
Tclin
Family:  IC
Novelty:  0.03089903
Score:  0.619
Data Source:  STRINGDB
GABRA1
Tclin
Family:  IC
Novelty:  0.0094079
Score:  0.618
Data Source:  STRINGDB
Nearest Tclin Targets (16)
Explore Nearest Tclin Targets
1 – 5 of 16
GABRQ
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
GABRB1
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
GABRG3
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
GABRA6
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
GABRA4
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
4
1
1
93.4
self reported educational attainment
3
4
3
5.7
91
mathematical ability
4
3
5
82.2
alkaline phosphatase measurement
2
1
1
10
81.5
3
3
0
1.1
76.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
93.4
self reported educational attainment
3
5.7
91
mathematical ability
5
82.2
alkaline phosphatase measurement
1
10
81.5
0
1.1
76.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase C like 1 (inactive)
VGNC:14339
470611
Macaque
phospholipase C like 1 (inactive)
698200
Mouse
MGI:3036262
227120
Rat
RGD:708420
84587
Dog
phospholipase C like 1 (inactive)
478858
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase C like 1 (inactive)
Macaque
phospholipase C like 1 (inactive)
Mouse
Rat
Dog
phospholipase C like 1 (inactive)
Publication Statistics
PubMed Score 27.52
PubMed score by year
PubTator Score 84.87
PubTator score by year
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Related Publications
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PMID
Year
Title