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Tchem
AGER
Advanced glycosylation end product-specific receptor

Protein Summary
Description
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular spa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375055
  • ENSP00000364195
  • ENSG00000204305
  • ENST00000375067
  • ENSP00000364208
  • ENST00000375069
  • ENSP00000364210
  • ENST00000375076
  • ENSP00000364217
  • ENST00000383275
  • ENSP00000372762
  • ENSG00000206320
  • ENST00000383279
  • ENSP00000372766
  • ENST00000412470
  • ENSP00000387853
  • ENSG00000229058
  • ENST00000426138
  • ENSP00000415144
  • ENSG00000230514
  • ENST00000427822
  • ENSP00000416042
  • ENSG00000231268
  • ENST00000432831
  • ENSP00000413391
  • ENSG00000237405
  • ENST00000436456
  • ENSP00000397227
  • ENSG00000234729
  • ENST00000438221
  • ENSP00000387887
  • ENST00000441180
  • ENSP00000388462
  • ENST00000441804
  • ENSP00000391743
  • ENST00000447921
  • ENSP00000395812
  • ENST00000449037
  • ENSP00000400667
  • ENST00000451115
  • ENSP00000401068
  • ENST00000453588
  • ENSP00000399686
  • ENST00000456918
  • ENSP00000409457
  • ENST00000547328
  • ENSP00000448579
  • ENST00000547651
  • ENSP00000449708
  • ENST00000548464
  • ENSP00000450134
  • ENST00000549758
  • ENSP00000447301
  • ENST00000550562
  • ENSP00000446835
  • ENST00000551254
  • ENSP00000449226
  • ENST00000551381
  • ENSP00000448979
  • ENST00000551827
  • ENSP00000449042

Symbol
  • RAGE
  • RAGE
  • SCARJ1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
co-expressed gene
0.89
disease
0.88
protein domain
0.85
gene perturbation
0.83


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1412.05   (req: < 5)
Gene RIFs: 757   (req: <= 3)
Antibodies: 781   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1412.05   (req: >= 5)
Gene RIFs: 757   (req: > 3)
Antibodies: 781   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0