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Tbio
NCF4
Neutrophil cytosol factor 4

Protein Summary
Description
Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex. The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which sugge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248899
  • ENSP00000248899
  • ENSG00000100365
  • ENST00000397147
  • ENSP00000380334

Symbol
  • SH3PXD4
  • NCF
  • CGD3
  • P40PHOX
  • SH3PXD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.72
virus perturbation
0.72
kinase perturbation
0.6
protein domain
0.58
tissue sample
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.52   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 458   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.52   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
5
6
93.4
eosinophil percentage of leukocytes
2
3
4
52
1
1
0
1.1
39.9
sum of eosinophil and basophil counts
1
1
1
36.3
basophil count
1
1
1
28.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
6
93.4
eosinophil percentage of leukocytes
4
52
0
1.1
39.9
sum of eosinophil and basophil counts
1
36.3
basophil count
1
28.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neutrophil cytosolic factor 4
695612
Mouse
MGI:109186
17972
Rat
RGD:1593157
500904
Dog
neutrophil cytosolic factor 4
VGNC:43651
481277
Horse
neutrophil cytosolic factor 4
VGNC:20587
100069566
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neutrophil cytosolic factor 4
Mouse
Rat
Dog
neutrophil cytosolic factor 4
Horse
neutrophil cytosolic factor 4
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15080-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (41)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Cellular responses to external stimuli
Cellular responses to stress
Class I MHC mediated antigen processing & presentation
Protein-Protein Interactions (146)
1 – 10 of 146
CYBB
Tchem
Family: IC
Novelty: 0.00054866
Score: 0.996
Data Source: Reactome,STRINGDB
CYBA
Tbio
Novelty: 0.00177762
Score: 0.994
Data Source: Reactome,STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.985
Data Source: Reactome,STRINGDB
NCF2
Tbio
Novelty: 0.00274685
Score: 0.98
Data Source: Reactome,STRINGDB
NCF1
Tbio
Novelty: 0.00120288
Score: 0.972
Data Source: Reactome,STRINGDB
NOX1
Tchem
Family: Enzyme
Novelty: 0.0016839
Score: 0.946
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.944
Data Source: Reactome,STRINGDB
VAV1
Tchem
Novelty: 0.00180518
Score: 0.937
Data Source: STRINGDB
NOXA1
Tbio
Family: Enzyme
Novelty: 0.03052419
Score: 0.923
Data Source: STRINGDB
VCAM1
Tchem
Novelty: 0.00022504
Score: 0.919
Data Source: STRINGDB
Publication Statistics
PubMed Score  134.52

PubMed score by year
PubTator Score  139.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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