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Tchem
CDK5R1
Cyclin-dependent kinase 5 activator 1

Protein Summary
Description
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolongi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313401
  • ENSP00000318486
  • ENSG00000176749

Symbol
  • CDK5R
  • NCK5A
  • p23
  • p25
  • p35
  • CDK5R
  • NCK5A
  • CDK5P35
  • p35nck5a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.95
cellular component
0.9
PubMedID
0.69
biological term
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.85   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.85   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
42.3
emphysema pattern measurement
1
1
1
21.5
1
1
0
1.1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
42.3
emphysema pattern measurement
1
21.5
0
1.1
2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 5 regulatory subunit 1
VGNC:12050
747897
Macaque
cyclin dependent kinase 5 regulatory subunit 1
714274
Mouse
MGI:101764
12569
Rat
RGD:629472
116671
Dog
cyclin dependent kinase 5 regulatory subunit 1
VGNC:39055
491154
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 5 regulatory subunit 1
Macaque
cyclin dependent kinase 5 regulatory subunit 1
Mouse
Rat
Dog
cyclin dependent kinase 5 regulatory subunit 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15078-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (72)
Activated NTRK2 signals through CDK5 (R-HSA-9032845)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through CDK5
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through CDK5
Axon guidance
CRMPs in Sema3A signaling
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Developmental Biology
Gene Ontology Terms (65)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ARUK-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (95)
1 – 10 of 95
CDK5
Tchem
Family:  Kinase
Novelty:  0.00071394
p_int:  0.999904453
p_ni:  0.000095546
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
p_int:  0.995852078
p_ni:  0.004147922
Score:  0.598
Data Source:  BioPlex,STRINGDB
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.985916976
p_ni:  0.013702339
p_wrong:  0.000380684
Score:  0.221
Data Source:  BioPlex,STRINGDB
PLPBP
Tbio
Family:  Enzyme
Novelty:  0.04352366
p_int:  0.98130283
p_ni:  0.016356483
p_wrong:  0.002340687
Score:  0.211
Data Source:  BioPlex,STRINGDB
MVB12A
Tbio
Novelty:  0.09794
p_int:  0.971174708
p_ni:  0.028803569
p_wrong:  0.000021723
Score:  0.189
Data Source:  BioPlex,STRINGDB
DENR
Tbio
Novelty:  0.00653432
p_int:  0.95407376
p_ni:  0.045898463
p_wrong:  0.000027776
Score:  0.169
Data Source:  BioPlex,STRINGDB
UBE2T
Tbio
Novelty:  0.02718799
p_int:  0.931836625
p_ni:  0.067252343
p_wrong:  0.000911032
Score:  0.204
Data Source:  BioPlex,STRINGDB
HMGCS1
Tchem
Family:  Enzyme
Novelty:  0.01089288
p_int:  0.874584133
p_ni:  0.121319936
p_wrong:  0.004095931
Score:  0.204
Data Source:  BioPlex,STRINGDB
MMAB
Tbio
Family:  Enzyme
Novelty:  0.01681296
p_int:  0.840781707
p_ni:  0.159050329
p_wrong:  0.000167965
Score:  0.157
Data Source:  BioPlex,STRINGDB
RSPRY1
Tdark
Novelty:  0.26883105
p_int:  0.795196077
p_ni:  0.204509299
p_wrong:  0.000294624
Data Source:  BioPlex
Publication Statistics
PubMed Score  88.85

PubMed score by year
PubTator Score  285.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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