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Tchem
P2RY6
P2Y purinoceptor 6

Protein Summary
Description
Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349767
  • ENSP00000309771
  • ENSG00000171631
  • ENST00000393590
  • ENSP00000377215
  • ENST00000393591
  • ENSP00000377216
  • ENST00000393592
  • ENSP00000377217
  • ENST00000538328
  • ENSP00000442990
  • ENST00000540124
  • ENSP00000442551
  • ENST00000540342
  • ENSP00000443427
  • ENST00000542092
  • ENSP00000445652
  • ENST00000618468
  • ENSP00000480966

Symbol
  • P2Y6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.75
tissue sample
0.75
small molecule perturbation
0.67
transcription factor
0.67
ligand (chemical)
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.07   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.07   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (192)
CCKAR
Tclin
Family:  GPCR
Novelty:  0.00152339
Score:  0.95
Data Source:  STRINGDB
P2RY11
Tchem
Family:  GPCR
Novelty:  0.01380362
Score:  0.929
Data Source:  STRINGDB
LTB4R
Tchem
Family:  GPCR
Novelty:  0.00354427
Score:  0.923
Data Source:  STRINGDB
TAC1
Tbio
Novelty:  0.00006575
Score:  0.917
Data Source:  STRINGDB
KNG1
Tbio
Novelty:  0.00007684
Score:  0.917
Data Source:  STRINGDB
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
Score:  0.916
Data Source:  STRINGDB
GRK5
Tchem
Family:  Kinase
Novelty:  0.01108012
Score:  0.915
Data Source:  STRINGDB
P2RY2
Tclin
Family:  GPCR
Novelty:  0.00220741
Score:  0.915
Data Source:  STRINGDB
P2RY10
Tchem
Family:  GPCR
Novelty:  0.12674578
Score:  0.915
Data Source:  STRINGDB
P2RY1
Tchem
Family:  GPCR
Novelty:  0.00203299
Score:  0.915
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Nucleotide-like (purinergic) receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Nucleotide-like (purinergic) receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
3
4
97.4
basophil percentage of leukocytes
2
2
3
94.2
mean platelet volume
3
1
3
82.5
basophil percentage of granulocytes
1
1
1
75.7
FEV/FEC ratio
1
1
1
75
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
4
97.4
basophil percentage of leukocytes
3
94.2
mean platelet volume
3
82.5
basophil percentage of granulocytes
1
75.7
FEV/FEC ratio
1
75
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyrimidinergic receptor P2Y6
VGNC:7510
451410
Macaque
pyrimidinergic receptor P2Y6
718623
Mouse
MGI:2673874
233571
Rat
RGD:620269
117264
Dog
pyrimidinergic receptor P2Y6
VGNC:44218
485202
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyrimidinergic receptor P2Y6
Macaque
pyrimidinergic receptor P2Y6
Mouse
Rat
Dog
pyrimidinergic receptor P2Y6
Publication Statistics
PubMed Score 154.07
PubMed score by year
PubTator Score 181.02
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title