Tchem P2RY6 P2Y purinoceptor 6

Protein Summary

Description

Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

Uniprot Accession IDs

• Q15077
• Q15754
• P2Y6

Gene Name

• P2RY6

Ensembl ID

• ENST00000349767
• ENSP00000309771
• ENSG00000171631
• ENST00000393590
• ENSP00000377215
• ENST00000393591
• ENSP00000377216
• ENST00000393592
• ENSP00000377217
• ENST00000538328
• ENSP00000442990
• ENST00000540124
• ENSP00000442551
• ENST00000540342
• ENSP00000443427
• ENST00000542092
• ENSP00000445652
• ENST00000618468
• ENSP00000480966

Symbol

• P2Y6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.75
tissue sample	0.75
small molecule perturbation	0.67
transcription factor	0.67
ligand (chemical)	0.61

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Purinoceptor / P2y Receptor / P2y Purinoceptor 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.64   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 237   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.64   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 42

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1