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Tbio
EEA1
Early endosome antigen 1

Protein Summary
Description
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322349
  • ENSP00000317955
  • ENSG00000102189

Symbol
  • ZFYVE2
  • MST105
  • ZFYVE2
  • MSTP105
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.96
protein domain
0.85
cellular component
0.81
gene perturbation
0.78
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.52   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 461   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 321.52   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 461   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
1
0
5.7
63.6
cognitive function measurement
2
1
2
7.7
self reported educational attainment
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
0
5.7
63.6
cognitive function measurement
2
7.7
self reported educational attainment
1
6.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
early endosome antigen 1
VGNC:5362
467212
Macaque
early endosome antigen 1
710381
Mouse
MGI:2442192
216238
Rat
RGD:1310167
314764
Dog
early endosome antigen 1
VGNC:40205
475424
Species
Name
OMA
EggNOG
Inparanoid
Chimp
early endosome antigen 1
Macaque
early endosome antigen 1
Mouse
Rat
Dog
early endosome antigen 1
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (68)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Toll Like Receptor 9 (TLR9) Cascade
Reactome
Toll-like Receptor Cascades
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Toll Like Receptor 9 (TLR9) Cascade
Toll-like Receptor Cascades
Gene Ontology Terms (22)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (207)
1 – 10 of 207
NUP58
Tbio
Novelty: 0.08797454
p_int: 0.999968763
p_ni: 0.000031236
Score: 0.166
Data Source: BioPlex,STRINGDB
MLLT6
Tdark
Family: Epigenetic
Novelty: 0.03728427
p_int: 0.999881541
p_ni: 0.000118459
Score: 0.158
Data Source: BioPlex,STRINGDB
SYCE1
Tbio
Novelty: 0.05038876
p_int: 0.99949479
p_ni: 0.00050521
Data Source: BioPlex
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999123566
p_ni: 0.000876434
Data Source: BioPlex
SERPINB2
Tbio
Novelty: 0.00204345
p_int: 0.998690045
p_ni: 0.001309952
p_wrong: 3e-9
Score: 0.2
Data Source: BioPlex,STRINGDB
FUOM
Tbio
Family: Enzyme
Novelty: 0.0562349
p_int: 0.982050457
p_ni: 0.017949543
Score: 0.165
Data Source: BioPlex,STRINGDB
BMP1
Tchem
Novelty: 0.00299518
p_int: 0.975653675
p_ni: 0.024346325
Data Source: BioPlex
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.919884036
p_ni: 0.080115962
p_wrong: 2e-9
Data Source: BioPlex
FCGR2A
Tbio
Novelty: 0.00078918
p_int: 0.816563332
p_ni: 0.183436668
Score: 0.26
Data Source: BioPlex,STRINGDB
TMA16
Tdark
Novelty: 0.89810617
p_int: 0.789632009
p_ni: 0.210367991
Score: 0.179
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  321.52

PubMed score by year
PubTator Score  205.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer