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Tbio
ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

Protein Summary
Description
Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA. The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293217
  • ENSP00000293217
  • ENSG00000161533
  • ENST00000301608
  • ENSP00000301608

Symbol
  • ACOX
  • ACOX
  • SCOX
  • PALMCOX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
transcription factor perturbation
0.94
protein domain
0.92
molecular function
0.91
interacting protein
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.33   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 352   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.33   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
31.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
31.3
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA oxidase 1
VGNC:12023
454895
Macaque
acyl-CoA oxidase 1
705197
Mouse
MGI:1330812
11430
Rat
RGD:619757
50681
Dog
acyl-CoA oxidase 1
VGNC:37521
483322
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA oxidase 1
Macaque
acyl-CoA oxidase 1
Mouse
Rat
Dog
acyl-CoA oxidase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15067-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
Beta-oxidation of very long chain fatty acids (R-HSA-390247)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of very long chain fatty acids
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Name
Explore in Pharos
Explore in Source
Beta-oxidation of very long chain fatty acids
Fatty acid metabolism
Metabolism
Metabolism of lipids
PPARA activates gene expression
Gene Ontology Terms (31)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (239)
1 – 10 of 239
UBA5
Tbio
Novelty: 0.05089296
p_int: 0.999999059
p_ni: 9.41e-7
Score: 0.152
Data Source: BioPlex,STRINGDB
RIDA
Tbio
Family: Enzyme
Novelty: 0.01795892
p_int: 0.99932713
p_ni: 0.000672869
Score: 0.206
Data Source: BioPlex,STRINGDB
UBE2D2
Tbio
Novelty: 0.00603877
p_int: 0.999259516
p_ni: 0.000740484
Score: 0.917
Data Source: BioPlex,STRINGDB
LAD1
Tbio
Novelty: 0.03059679
p_int: 0.999008941
p_ni: 0.000991059
Data Source: BioPlex
ACBD7
Tdark
Novelty: 0.32019061
p_int: 0.998928387
p_ni: 0.001071613
Score: 0.292
Data Source: BioPlex,STRINGDB
ARL2
Tbio
Family: Enzyme
Novelty: 0.01989908
p_int: 0.99867174
p_ni: 0.00132826
Data Source: BioPlex
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.998573567
p_ni: 0.001426433
Data Source: BioPlex
DUSP14
Tbio
Family: Enzyme
Novelty: 0.04013065
p_int: 0.996056707
p_ni: 0.003943293
Data Source: BioPlex
KHDRBS2
Tbio
Novelty: 0.01986638
p_int: 0.99594209
p_ni: 0.00405791
Score: 0.176
Data Source: BioPlex,STRINGDB
TXNDC16
Tdark
Novelty: 0.25365147
p_int: 0.974756226
p_ni: 0.025243774
Data Source: BioPlex
Publication Statistics
PubMed Score  197.33

PubMed score by year
PubTator Score  267.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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