Tbio WDR43 WD repeat-containing protein 43

Protein Summary

Description

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.

Uniprot Accession IDs

• Q15061
• Q15395
• Q92577

Gene Name

• WDR43

Ensembl ID

• ENST00000407426
• ENSP00000384302
• ENSG00000163811

Symbol

• KIAA0007
• UTP5
• UTP5
• NET12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
disease perturbation	0.9
transcription factor binding site profile	0.78
tissue sample	0.64
transcription factor	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.77   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 74   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.77   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0