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Tbio
WDR43
WD repeat-containing protein 43

Protein Summary
Description
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407426
  • ENSP00000384302
  • ENSG00000163811

Symbol
  • KIAA0007
  • UTP5
  • UTP5
  • NET12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.9
transcription factor binding site profile
0.78
tissue sample
0.64
transcription factor
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.83   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.83   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (347)
UTP4
Tbio
Novelty:  0.06989008
p_int:  0.99999987
p_ni:  1.26e-7
p_wrong:  4e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
NOL7
Tbio
Novelty:  0.24085052
p_int:  0.99995558
p_ni:  0.000044114
p_wrong:  3.07e-7
Score:  0.843
Data Source:  BioPlex,STRINGDB
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.999908856
p_ni:  0.000091142
p_wrong:  2e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.999494266
p_ni:  0.000490434
p_wrong:  0.0000153
Score:  0.908
Data Source:  BioPlex,STRINGDB
C1D
Tbio
Novelty:  0.00997109
p_int:  0.999421018
p_ni:  0.000578981
Score:  0.92
Data Source:  BioPlex,STRINGDB
RBM4
Tbio
Novelty:  0.02034191
p_int:  0.997174228
p_ni:  0.002825768
p_wrong:  4e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.991408329
p_ni:  0.00832881
p_wrong:  0.000262861
Data Source:  BioPlex
WDR46
Tbio
Novelty:  0.19307408
p_int:  0.987853999
p_ni:  0.005367451
p_wrong:  0.00677855
Score:  0.999
Data Source:  BioPlex,STRINGDB
MPHOSPH10
Tbio
Novelty:  0.04846226
Score:  0.999
Data Source:  STRINGDB
HEATR1
Tbio
Novelty:  0.10365788
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
33.1
1
1
0
1.1
29
ferritin measurement
1
1
1
26.1
intraocular pressure measurement
1
1
1
14.2
self reported educational attainment
1
1
1
10.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
33.1
0
1.1
29
ferritin measurement
1
26.1
intraocular pressure measurement
1
14.2
self reported educational attainment
1
10.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 43
VGNC:422
459122
Macaque
WD repeat domain 43
704047
Mouse
MGI:1919765
72515
Rat
RGD:1565005
362703
Dog
WD repeat domain 43
VGNC:48367
475713
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 43
Macaque
WD repeat domain 43
Mouse
Rat
Dog
WD repeat domain 43
Publication Statistics
PubMed Score 9.83
PubMed score by year
PubTator Score 7.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title