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Tchem
BRD3
Bromodomain-containing protein 3

Protein Summary
Description
Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors (PubMed:18406326, PubMed:27105114). Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303407
  • ENSP00000305918
  • ENSG00000169925
  • ENST00000371834
  • ENSP00000360900

Symbol
  • KIAA0043
  • RING3L
  • ORFX
  • RING3L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.93
kinase perturbation
0.91
virus perturbation
0.85
kinase
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.19   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.19   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 239
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
4
96.5
sex hormone-binding globulin measurement
4
1
4
96
platelet count
3
3
2
3
90.1
mean platelet volume
2
3
4
70.9
red blood cell distribution width
3
3
4
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
96.5
sex hormone-binding globulin measurement
4
96
platelet count
2
3
90.1
mean platelet volume
4
70.9
red blood cell distribution width
4
66.8
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (104)
1 – 10 of 104
FAM90A1
Tdark
Novelty: 0.95155075
p_int: 1
Score: 0.811
Data Source: BioPlex,STRINGDB
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.999999709
p_ni: 2.88e-7
p_wrong: 4e-9
Score: 0.274
Data Source: BioPlex,STRINGDB
BRD2
Tchem
Family: Epigenetic
Novelty: 0.00531003
p_int: 0.99999957
p_ni: 4.25e-7
p_wrong: 5e-9
Score: 0.922
Data Source: BioPlex,STRINGDB
CAMKV
Tbio
Family: Kinase
Novelty: 0.17794181
p_int: 0.999980529
p_ni: 0.000019464
p_wrong: 7e-9
Score: 0.326
Data Source: BioPlex,STRINGDB
IGHA2
Tbio
p_int: 0.963956369
p_ni: 0.035953946
p_wrong: 0.000089684
Data Source: BioPlex
DMAP1
Tbio
Family: Enzyme
Novelty: 0.03152166
Score: 0.93
Data Source: STRINGDB
HLA-DMA
Tbio
Novelty: 0.00405566
Score: 0.878
Data Source: STRINGDB
BRD4
Tchem
Family: Epigenetic
Novelty: 0.0013933
Score: 0.859
Data Source: STRINGDB
NUTM1
Tbio
Novelty: 0.00390466
Score: 0.811
Data Source: STRINGDB
HLA-DOA
Tbio
Novelty: 0.01222732
Score: 0.801
Data Source: STRINGDB
Publication Statistics
PubMed Score  284.19

PubMed score by year
PubTator Score  36.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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