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Tchem
EIF4H
Eukaryotic translation initiation factor 4H

Protein Summary
Description
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265753
  • ENSP00000265753
  • ENSG00000106682
  • ENST00000353999
  • ENSP00000265754

Symbol
  • KIAA0038
  • WBSCR1
  • WSCR1
  • WSCR1
  • WBSCR1
  • eIF-4H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
virus perturbation
1
disease perturbation
0.99
interacting protein
0.99
kinase perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.51   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.51   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL1542453
chemical structure image
Pathways (10)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-HSA-72662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Reactome
Cap-dependent Translation Initiation
Reactome
Eukaryotic Translation Initiation
Reactome
GTP hydrolysis and joining of the 60S ribosomal subunit
Reactome
L13a-mediated translational silencing of Ceruloplasmin expression
Name
Explore in Pharos
Explore in Source
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Cap-dependent Translation Initiation
Eukaryotic Translation Initiation
GTP hydrolysis and joining of the 60S ribosomal subunit
L13a-mediated translational silencing of Ceruloplasmin expression
Gene Ontology Terms (20)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (293)
1 – 10 of 293
EIF4A1
Tchem
Novelty: 0.0043238
Score: 0.994
Data Source: Reactome,STRINGDB
EIF4E
Tchem
Novelty: 0.00088513
Score: 0.979
Data Source: Reactome,STRINGDB
EIF4A2
Tbio
Novelty: 0.00471357
Score: 0.978
Data Source: Reactome,STRINGDB
EIF3F
Tbio
Novelty: 0.03659119
Score: 0.976
Data Source: STRINGDB
EIF4G1
Tbio
Novelty: 0.00219215
Score: 0.976
Data Source: Reactome,STRINGDB
EIF3G
Tbio
Novelty: 0.06880717
Score: 0.975
Data Source: STRINGDB
RPS20
Tbio
Novelty: 0.01116958
Score: 0.968
Data Source: STRINGDB
EIF5
Tbio
Novelty: 0.01121202
Score: 0.966
Data Source: STRINGDB
RPL4
Tbio
Novelty: 0.0080985
Score: 0.964
Data Source: STRINGDB
EIF3I
Tbio
Novelty: 0.07521172
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.51

PubMed score by year
PubTator Score  22.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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