EIF4H
Eukaryotic translation initiation factor 4H
Protein Summary
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
- ENST00000265753
- ENSP00000265753
- ENSG00000106682
- ENST00000353999
- ENSP00000265754
- KIAA0038
- WBSCR1
- WSCR1
- WSCR1
- WBSCR1
- eIF-4H
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
virus perturbation | 1 | ||
disease perturbation | 0.99 | ||
interacting protein | 0.99 | ||
kinase perturbation | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.45 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 183 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.45 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 183 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0