ARHGEF6
Rho guanine nucleotide exchange factor 6
Protein Summary
Acts as a RAC1 guanine nucleotide exchange factor (GEF). Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]
- ENST00000250617
- ENSP00000250617
- ENSG00000129675
- ENST00000370620
- ENSP00000359654
- ENST00000370622
- ENSP00000359656
- COOL2
- KIAA0006
- PIXA
- PIXA
- COOL2
- MRX46
- Cool-2
- alphaPIX
- alpha-PIX
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.96 | ||
protein domain | 0.85 | ||
hub protein | 0.79 | ||
kinase perturbation | 0.71 | ||
cell type or tissue | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 62.39 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 134 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 62.39 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 134 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0