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Tbio
ARHGEF6
Rho guanine nucleotide exchange factor 6

Protein Summary
Description
Acts as a RAC1 guanine nucleotide exchange factor (GEF). Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250617
  • ENSP00000250617
  • ENSG00000129675
  • ENST00000370620
  • ENSP00000359654
  • ENST00000370622
  • ENSP00000359656

Symbol
  • COOL2
  • KIAA0006
  • PIXA
  • PIXA
  • COOL2
  • MRX46
  • Cool-2
  • alphaPIX
  • alpha-PIX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
protein domain
0.85
hub protein
0.79
kinase perturbation
0.71
cell type or tissue
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.34   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.34   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
1
2
46.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
46.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rac/Cdc42 guanine nucleotide exchange factor 6
VGNC:7543
473803
Macaque
Rac/Cdc42 guanine nucleotide exchange factor 6
693976
Mouse
MGI:1920591
73341
Rat
RGD:1359674
363509
Dog
Rac/Cdc42 guanine nucleotide exchange factor 6
VGNC:38091
610290
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rac/Cdc42 guanine nucleotide exchange factor 6
Macaque
Rac/Cdc42 guanine nucleotide exchange factor 6
Mouse
Rat
Dog
Rac/Cdc42 guanine nucleotide exchange factor 6
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15052-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Death Receptor Signalling
Protein-Protein Interactions (134)
1 – 10 of 134
GIT2
Tbio
Family: Enzyme
Novelty: 0.01530665
p_int: 1
Score: 0.998
Data Source: BioPlex,STRINGDB
ARHGEF7
Tbio
Novelty: 0.00919946
p_int: 0.999999999
p_ni: 1e-9
p_wrong: 1e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
GIT1
Tbio
Family: Enzyme
Novelty: 0.01022741
p_int: 0.999999994
p_ni: 6e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
FBXO28
Tbio
Novelty: 0.10548865
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.791
Data Source: BioPlex,STRINGDB
LPXN
Tbio
Novelty: 0.00796678
p_int: 0.999999766
p_ni: 2.34e-7
Score: 0.765
Data Source: BioPlex,STRINGDB
PAK1
Tchem
Family: Kinase
Novelty: 0.00411227
p_int: 0.999998822
p_ni: 0.000001178
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.999997916
p_ni: 0.000001833
p_wrong: 2.51e-7
Score: 0.645
Data Source: BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty: 0.01605171
p_int: 0.999997586
p_ni: 0.000002408
p_wrong: 6e-9
Data Source: BioPlex
NCKIPSD
Tbio
Novelty: 0.07453111
p_int: 0.999996892
p_ni: 0.000003106
p_wrong: 1e-9
Score: 0.744
Data Source: BioPlex,STRINGDB
PAK2
Tchem
Family: Kinase
Novelty: 0.0149123
p_int: 0.999989947
p_ni: 0.000009989
p_wrong: 6.4e-8
Score: 0.988
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  45.34

PubMed score by year
PubTator Score  22.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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