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Tbio
IQCB1
IQ calmodulin-binding motif-containing protein 1

Protein Summary
Description
Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (PubMed:21565611, PubMed:23446637). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed:25552655). This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosom ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310864
  • ENSP00000311505
  • ENSG00000173226
  • ENST00000349820
  • ENSP00000323756
  • ENST00000393650
  • ENSP00000377261

Symbol
  • KIAA0036
  • NPHP5
  • PIQ
  • NPHP5
  • SLSN5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
interacting protein
0.82
tissue sample
0.7
cellular component
0.62
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.21   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.21   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
86.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
86.3
Pathways (4)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (206)
1 – 10 of 206
CEP290
Tbio
Novelty: 0.00526375
p_int: 0.999999999
p_ni: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
RNF135
Tbio
Family: Enzyme
Novelty: 0.05600338
p_int: 0.999715562
p_ni: 0.000281621
p_wrong: 0.000002817
Score: 0.199
Data Source: BioPlex,STRINGDB
LTBR
Tbio
Novelty: 0.003823
p_int: 0.998994085
p_ni: 0.001005915
Data Source: BioPlex
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.996490602
p_ni: 0.003509398
Data Source: BioPlex
CDH5
Tbio
Novelty: 0.00072649
p_int: 0.995581356
p_ni: 0.004418644
Score: 0.198
Data Source: BioPlex,STRINGDB
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.992868862
p_ni: 0.007131138
Data Source: BioPlex
PEG10
Tbio
Novelty: 0.00478545
p_int: 0.988000097
p_ni: 0.011999903
Score: 0.527
Data Source: BioPlex,STRINGDB
EIF2B5
Tbio
Novelty: 0.0102209
p_int: 0.986559911
p_ni: 0.013440089
Data Source: BioPlex
EXOC1
Tbio
Novelty: 0.01073858
p_int: 0.981092675
p_ni: 0.018907325
Score: 0.196
Data Source: BioPlex,STRINGDB
CA14
Tclin
Family: Enzyme
Novelty: 0.00864764
p_int: 0.975249028
p_ni: 0.024750972
Data Source: BioPlex
Publication Statistics
PubMed Score  35.21

PubMed score by year
PubTator Score  35.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer