Tbio MLC1 Membrane protein MLC1

Protein Summary

Description

Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15049
• B3KW61
• B7Z659
• Q5JZ83
• Q8TAG4
• Q96RP5
• Q9UGY8

Gene Name

• MLC1

Ensembl ID

• ENST00000311597
• ENSP00000310375
• ENSG00000100427
• ENST00000395876
• ENSP00000379216

Symbol

• KIAA0027
• WKL1
• VL
• LVM
• MLC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.56
tissue sample	0.56
gene perturbation	0.55
cell line	0.53
PubMedID	0.51

Protein Classes

DTO Classes

Protein / Ion Channel / Membrane Protein Mlc1 Family / Membrane Protein Mlc1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.9   (req: < 5)

Gene RIFs: 51   (req: <= 3)

Antibodies: 154   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.9   (req: >= 5)

Gene RIFs: 51   (req: > 3)

Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0