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Tbio
SETDB1
Histone-lysine N-methyltransferase SETDB1

Protein Summary
Description
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271640
  • ENSP00000271640
  • ENSG00000143379
  • ENST00000368962
  • ENSP00000357958
  • ENST00000368969
  • ENSP00000357965

Symbol
  • KIAA0067
  • KMT1E
  • ESET
  • KG1T
  • KMT1E
  • TDRD21
  • H3-K9-HMTase4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
ligand (protein) perturbation
0.96
histone modification site profile
0.87
hub protein
0.85
molecular function
0.79


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.79   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 356   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.79   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SET domain bifurcated 1
VGNC:8102
469481
Mouse
MGI:1934229
84505
Rat
RGD:1308370
689883
Dog
SET domain bifurcated 1
VGNC:46060
483186
Horse
SET domain bifurcated 1
VGNC:22879
100059254
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SET domain bifurcated 1
Mouse
Rat
Dog
SET domain bifurcated 1
Horse
SET domain bifurcated 1
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15047-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (230)
1 – 10 of 230
ATF7IP
Tbio
Novelty: 0.04269323
p_int: 1
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999999898
p_ni: 1.02e-7
Data Source: BioPlex
MCUB
Tbio
Novelty: 0.0486243
p_int: 0.999999716
p_ni: 2.82e-7
p_wrong: 1e-9
Score: 0.674
Data Source: BioPlex,STRINGDB
VHL
Tchem
Family: Enzyme
Novelty: 0.00285782
p_int: 0.999997739
p_ni: 0.000002261
Data Source: BioPlex
FAF2
Tbio
Novelty: 0.03048598
p_int: 0.999995156
p_ni: 0.000004844
Score: 0.382
Data Source: BioPlex,STRINGDB
MAGEA1
Tbio
Novelty: 0.00506874
p_int: 0.999991164
p_ni: 0.000008835
p_wrong: 2e-9
Data Source: BioPlex
CLPB
Tbio
Family: Enzyme
Novelty: 0.00209789
p_int: 0.999422299
p_ni: 0.000577701
Score: 0.359
Data Source: BioPlex,STRINGDB
CRYAA
Tbio
Novelty: 0.01914081
p_int: 0.998795535
p_ni: 0.001204463
p_wrong: 2e-9
Data Source: BioPlex
WASHC3
Tdark
Novelty: 0.18307321
p_int: 0.996402796
p_ni: 0.00359719
p_wrong: 1.4e-8
Score: 0.168
Data Source: BioPlex,STRINGDB
SUV39H1
Tchem
Family: Epigenetic
Novelty: 0.00417439
p_int: 0.996111025
p_ni: 0.003888964
p_wrong: 1.1e-8
Score: 0.589
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  168.79

PubMed score by year
PubTator Score  94.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer