Protein Summary
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739). (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to ...more
- ENST00000302445
- ENSP00000303043
- ENSG00000065427
- ENST00000319410
- ENSP00000325448
- KIAA0070
- KRS
- KARS1
- KARS2
- CMTRIB
- DFNB89
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 1 | ||
interacting protein | 1 | ||
kinase perturbation | 1 | ||
molecular function | 0.98 | ||
protein domain | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 281.45 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 202 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 281.45 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 202 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 54
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (54)
Protein-Protein Interactions (303)
RARS
Family: Enzyme
Novelty: 0.00099479
p_int: 0.999994549
p_ni: 0.000005451
Score: 0.999
Data Source: BioPlex,STRINGDB
TARSL2
Family: Enzyme
Novelty: 0.02406282
p_int: 0.999993971
p_ni: 0.000006029
Score: 0.969
Data Source: BioPlex,STRINGDB
SDCCAG8
Novelty: 0.0431837
p_int: 0.999988727
p_ni: 0.000011152
p_wrong: 1.21e-7
Score: 0.741
Data Source: BioPlex,STRINGDB
AIMP2
Family: Enzyme
Novelty: 0.03283387
p_int: 0.999982175
p_ni: 0.000017825
Score: 0.999
Data Source: BioPlex,STRINGDB
AIMP1
Family: Enzyme
Novelty: 0.00743447
p_int: 0.9996742
p_ni: 0.0003258
Score: 0.998
Data Source: BioPlex,STRINGDB
DARS
Family: Enzyme
Novelty: 0.01101888
p_int: 0.999149756
p_ni: 0.000850244
Score: 0.994
Data Source: BioPlex,STRINGDB
EPRS
Family: Enzyme
Novelty: 0.00084896
p_int: 0.998884029
p_ni: 0.001115971
Score: 0.999
Data Source: BioPlex,STRINGDB
EEF1E1
Novelty: 0.06216577
p_int: 0.998835167
p_ni: 0.001164833
Score: 0.994
Data Source: BioPlex,STRINGDB
IARS
Family: Enzyme
Novelty: 0.00539046
p_int: 0.998494698
p_ni: 0.001505302
Score: 0.999
Data Source: BioPlex,STRINGDB
LARS
Family: Enzyme
Novelty: 0.00361711
p_int: 0.998340387
p_ni: 0.001659613
Score: 0.998
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (10)
Reactome (8)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytosolic tRNA aminoacylation | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Mitochondrial tRNA aminoacylation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytosolic tRNA aminoacylation | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Metabolism of proteins | ||||
Mitochondrial tRNA aminoacylation | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (7)
Components (7)
Processes (19)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
response to darapladib | 1 | 1 | 0 | 4.2 | 33.1 | ||||
Diarrhea | 1 | 1 | 0 | 4.2 | 33.1 | ||||
smoking status measurement | 1 | 2 | 2 | 33.1 | |||||
age at first sexual intercourse measurement | 1 | 1 | 1 | 28.1 | |||||
smoking initiation | 1 | 1 | 1 | 26.1 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
response to darapladib | 0 | 4.2 | 33.1 | ||||
Diarrhea | 0 | 4.2 | 33.1 | ||||
smoking status measurement | 2 | 33.1 | |||||
age at first sexual intercourse measurement | 1 | 28.1 | |||||
smoking initiation | 1 | 26.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | lysyl-tRNA synthetase | VGNC:13722 | 454252 | |||||
Mouse | MGI:1934754 | 85305 | ||||||
Rat | RGD:1359653 | 292028 | ||||||
Dog | lysyl-tRNA synthetase | VGNC:42207 | 479644 | |||||
Horse | lysyl-tRNA synthetase | VGNC:19239 | 100055335 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | lysyl-tRNA synthetase | |||||
Mouse | ||||||
Rat | ||||||
Dog | lysyl-tRNA synthetase | |||||
Horse | lysyl-tRNA synthetase | |||||
Publication Statistics
PubMed Score 281.45
PubMed score by year
PubTator Score 138.50
PubTator score by year
Related Publications
Text Mined References (71)
GeneRif Annotations (33)
Items per page:
0 of 0
PMID | Year | Title |
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