Tchem KARS Lysine--tRNA ligase

Protein Summary

Description

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739). (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15046
• A8MSK1
• D3DUK4
• O14946
• Q96J25
• Q9HB23

Gene Name

• KARS

Ensembl ID

• ENST00000302445
• ENSP00000303043
• ENSG00000065427
• ENST00000319410
• ENSP00000325448

Symbol

• KIAA0070
• KRS
• KARS1
• KARS2
• CMTRIB
• DFNB89

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
interacting protein	1
kinase perturbation	1
molecular function	0.98
protein domain	0.92

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Lysine--trna Ligase

Protein / Ligase / Aminoacyl-trna Synthetase / Lysine--trna Ligase

DTO Classes

Protein / Enzyme / Ligase / Aminoacyl-trna Synthetase / Lysine--trna Ligase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.93   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.93   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0