Protein Classes
Protein Summary
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739). (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to ...more
- ENST00000302445
- ENSP00000303043
- ENSG00000065427
- ENST00000319410
- ENSP00000325448
- KIAA0070
- KRS
- KARS1
- KARS2
- CMTRIB
- DFNB89
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 1 | ||
interacting protein | 1 | ||
kinase perturbation | 1 | ||
molecular function | 0.98 | ||
protein domain | 0.92 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 304.17 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 202 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 304.17 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 202 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 45
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (45)
1 – 10 of 45
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (10)
Reactome (8)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytosolic tRNA aminoacylation | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Mitochondrial tRNA aminoacylation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytosolic tRNA aminoacylation | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Metabolism of proteins | ||||
Mitochondrial tRNA aminoacylation | ||||
Gene Ontology Terms (33)
Functions (7)
Components (7)
Processes (19)
Items per page:
10
1 – 7 of 7
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (303)
1 – 10 of 303
RARS
Family: Enzyme
Novelty: 0.00081224
p_int: 0.999994549
p_ni: 0.000005451
Score: 0.999
Data Source: BioPlex,STRINGDB
TARSL2
Family: Enzyme
Novelty: 0.0300025
p_int: 0.999993971
p_ni: 0.000006029
Score: 0.969
Data Source: BioPlex,STRINGDB
SDCCAG8
Novelty: 0.06798507
p_int: 0.999988727
p_ni: 0.000011152
p_wrong: 1.21e-7
Score: 0.741
Data Source: BioPlex,STRINGDB
AIMP2
Family: Enzyme
Novelty: 0.03974199
p_int: 0.999982175
p_ni: 0.000017825
Score: 0.999
Data Source: BioPlex,STRINGDB
AIMP1
Family: Enzyme
Novelty: 0.00828433
p_int: 0.9996742
p_ni: 0.0003258
Score: 0.998
Data Source: BioPlex,STRINGDB
DARS
Family: Enzyme
Novelty: 0.01186323
p_int: 0.999149756
p_ni: 0.000850244
Score: 0.994
Data Source: BioPlex,STRINGDB
EPRS
Family: Enzyme
Novelty: 0.00072148
p_int: 0.998884029
p_ni: 0.001115971
Score: 0.999
Data Source: BioPlex,STRINGDB
EEF1E1
Novelty: 0.07766287
p_int: 0.998835167
p_ni: 0.001164833
Score: 0.994
Data Source: BioPlex,STRINGDB
IARS
Family: Enzyme
Novelty: 0.0033571
p_int: 0.998494698
p_ni: 0.001505302
Score: 0.999
Data Source: BioPlex,STRINGDB
LARS
Family: Enzyme
Novelty: 0.00167582
p_int: 0.998340387
p_ni: 0.001659613
Score: 0.998
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 304.17
PubMed score by year
PubTator Score 138.5
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEES
1-70
VDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGG
70-140
KLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCL
140-210
HMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVA
210-280
KPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDL
280-350
MEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETR
350-420
KILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFV
420-490
MKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTD
490-560
SNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
560-597
MAAVQAAEVKVDGSEPKLSKNELKRRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPLAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPEDKKENVATTDTLESTTVGTSV
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