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Tchem
KARS
Lysine--tRNA ligase

Protein Summary
Description
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479). When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690). Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739). (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302445
  • ENSP00000303043
  • ENSG00000065427
  • ENST00000319410
  • ENSP00000325448

Symbol
  • KIAA0070
  • KRS
  • KARS1
  • KARS2
  • CMTRIB
  • DFNB89
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
kinase perturbation
1
molecular function
0.98
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.45   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 281.45   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to darapladib
1
1
0
4.2
33.1
Diarrhea
1
1
0
4.2
33.1
smoking status measurement
1
2
2
33.1
age at first sexual intercourse measurement
1
1
1
28.1
smoking initiation
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to darapladib
0
4.2
33.1
Diarrhea
0
4.2
33.1
smoking status measurement
2
33.1
age at first sexual intercourse measurement
1
28.1
smoking initiation
1
26.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysyl-tRNA synthetase
VGNC:13722
454252
Mouse
MGI:1934754
85305
Rat
RGD:1359653
292028
Dog
lysyl-tRNA synthetase
VGNC:42207
479644
Horse
lysyl-tRNA synthetase
VGNC:19239
100055335
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysyl-tRNA synthetase
Mouse
Rat
Dog
lysyl-tRNA synthetase
Horse
lysyl-tRNA synthetase
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15046-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism
Metabolism of amino acids and derivatives
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Gene Ontology Terms (33)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (303)
1 – 10 of 303
RARS
Tchem
Family:  Enzyme
Novelty:  0.00099479
p_int:  0.999994549
p_ni:  0.000005451
Score:  0.999
Data Source:  BioPlex,STRINGDB
TARSL2
Tbio
Family:  Enzyme
Novelty:  0.02406282
p_int:  0.999993971
p_ni:  0.000006029
Score:  0.969
Data Source:  BioPlex,STRINGDB
SDCCAG8
Tbio
Novelty:  0.0431837
p_int:  0.999988727
p_ni:  0.000011152
p_wrong:  1.21e-7
Score:  0.741
Data Source:  BioPlex,STRINGDB
AIMP2
Tchem
Family:  Enzyme
Novelty:  0.03283387
p_int:  0.999982175
p_ni:  0.000017825
Score:  0.999
Data Source:  BioPlex,STRINGDB
AIMP1
Tbio
Family:  Enzyme
Novelty:  0.00743447
p_int:  0.9996742
p_ni:  0.0003258
Score:  0.998
Data Source:  BioPlex,STRINGDB
DARS
Tbio
Family:  Enzyme
Novelty:  0.01101888
p_int:  0.999149756
p_ni:  0.000850244
Score:  0.994
Data Source:  BioPlex,STRINGDB
EPRS
Tchem
Family:  Enzyme
Novelty:  0.00084896
p_int:  0.998884029
p_ni:  0.001115971
Score:  0.999
Data Source:  BioPlex,STRINGDB
EEF1E1
Tbio
Novelty:  0.06216577
p_int:  0.998835167
p_ni:  0.001164833
Score:  0.994
Data Source:  BioPlex,STRINGDB
IARS
Tchem
Family:  Enzyme
Novelty:  0.00539046
p_int:  0.998494698
p_ni:  0.001505302
Score:  0.999
Data Source:  BioPlex,STRINGDB
LARS
Tchem
Family:  Enzyme
Novelty:  0.00361711
p_int:  0.998340387
p_ni:  0.001659613
Score:  0.998
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  281.45

PubMed score by year
PubTator Score  138.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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