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Tbio
SLC39A14
Zinc transporter ZIP14

Protein Summary
Description
Broad-scope metal ion transporter with a preference for zinc uptake (PubMed:29621230). Also mediates cellular uptake of nontransferrin-bound iron. This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240095
  • ENSP00000240095
  • ENSG00000104635
  • ENST00000289952
  • ENSP00000289952
  • ENST00000359741
  • ENSP00000352779
  • ENST00000381237
  • ENSP00000370635

Symbol
  • KIAA0062
  • ZIP14
  • HCIN
  • NET34
  • ZIP14
  • cig19
  • HMNDYT2
  • LZT-Hs4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
PubMedID
0.93
transcription factor binding site profile
0.9
virus perturbation
0.9
microRNA
0.83


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.89   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.89   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 14
VGNC:7736
464044
Mouse
MGI:2384851
213053
Rat
RGD:1307026
306009
Dog
solute carrier family 39 member 14
VGNC:46402
486124
Horse
solute carrier family 39 member 14
VGNC:50766
100057232
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 14
Mouse
Rat
Dog
solute carrier family 39 member 14
Horse
solute carrier family 39 member 14
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15043-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Metal ion SLC transporters (R-HSA-425410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metal ion SLC transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Reactome
Zinc influx into cells by the SLC39 gene family
Name
Explore in Pharos
Explore in Source
Metal ion SLC transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Zinc influx into cells by the SLC39 gene family
Protein-Protein Interactions (60)
1 – 10 of 60
SLC39A1
Tbio
Family: Transporter
Novelty: 0.00678191
Score: 0.858
Data Source: STRINGDB
SLC30A10
Tbio
Family: Transporter
Novelty: 0.00448153
Score: 0.839
Data Source: STRINGDB
SLC11A2
Tchem
Family: Transporter
Novelty: 0.00189409
Score: 0.823
Data Source: STRINGDB
SLC30A4
Tbio
Family: Transporter
Novelty: 0.02209
Score: 0.819
Data Source: STRINGDB
SLC39A8
Tbio
Family: Transporter
Novelty: 0.00923197
Score: 0.815
Data Source: STRINGDB
SLC39A2
Tbio
Family: Transporter
Novelty: 0.01886854
Score: 0.813
Data Source: STRINGDB
SLC30A6
Tbio
Family: Transporter
Novelty: 0.06083299
Score: 0.812
Data Source: STRINGDB
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
Score: 0.8
Data Source: STRINGDB
SLC30A1
Tbio
Family: Transporter
Novelty: 0.00528427
Score: 0.794
Data Source: STRINGDB
SLC30A9
Tbio
Family: Transporter
Novelty: 0.07156604
Score: 0.78
Data Source: STRINGDB
Publication Statistics
PubMed Score  101.89

PubMed score by year
PubTator Score  36.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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