EFTUD2
116 kDa U5 small nuclear ribonucleoprotein component
Protein Summary
Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP. This gene encodes a GTPase which is a component of the spliceosome complex which processes precursor mRNAs to produce mature mRNAs. Mutations in this gene are associated with mandibulofacial dysostosis with microcephaly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
- ENST00000402521
- ENSP00000385873
- ENSG00000108883
- ENST00000426333
- ENSP00000392094
- ENST00000591382
- ENSP00000467805
- ENST00000592576
- ENSP00000465058
- KIAA0031
- SNRP116
- MFDM
- MFDGA
- Snu114
- Snrp116
- SNRNP116
- U5-116KD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
interacting protein | 1 | ||
protein domain | 1 | ||
transcription factor perturbation | 0.96 | ||
molecular function | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.11 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 221 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 77.11 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 221 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0