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Tbio
EFTUD2
116 kDa U5 small nuclear ribonucleoprotein component

Protein Summary
Description
Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP. This gene encodes a GTPase which is a component of the spliceosome complex which processes precursor mRNAs to produce mature mRNAs. Mutations in this gene are associated with mandibulofacial dysostosis with microcephaly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402521
  • ENSP00000385873
  • ENSG00000108883
  • ENST00000426333
  • ENSP00000392094
  • ENST00000591382
  • ENSP00000467805
  • ENST00000592576
  • ENSP00000465058

Symbol
  • KIAA0031
  • SNRP116
  • MFDM
  • MFDGA
  • Snu114
  • Snrp116
  • SNRNP116
  • U5-116KD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
protein domain
1
transcription factor perturbation
0.96
molecular function
0.95


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.01   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.01   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (550)
CD2BP2
Tbio
Novelty:  0.01440995
p_int:  0.999069373
p_ni:  0.000930627
Score:  0.994
Data Source:  BioPlex,STRINGDB
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.967588239
p_ni:  0.032411761
Score:  0.833
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.951239242
p_ni:  0.048760758
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRNP40
Tbio
Novelty:  0.16791896
p_int:  0.939700624
p_ni:  0.060299376
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
p_int:  0.926436121
p_ni:  0.073563879
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPGP15
Tdark
p_int:  0.913301459
p_ni:  0.086698541
Data Source:  BioPlex
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.911137477
p_ni:  0.088862523
Score:  0.998
Data Source:  BioPlex,STRINGDB
AAR2
Tbio
Novelty:  0.05805748
p_int:  0.906155229
p_ni:  0.093844771
Score:  0.995
Data Source:  BioPlex,STRINGDB
DDX23
Tbio
Family:  Enzyme
Novelty:  0.03592096
p_int:  0.821131859
p_ni:  0.178868141
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.800259695
p_ni:  0.199740305
Score:  0.994
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Reactome
mRNA Splicing - Minor Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
2
2
63.7
biological sex
1
1
1
49.5
electrocardiography
1
1
1
29
hip bone size
1
1
1
17.1
chronotype measurement
1
1
1
6.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
63.7
biological sex
1
49.5
electrocardiography
1
29
hip bone size
1
17.1
chronotype measurement
1
6.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
elongation factor Tu GTP binding domain containing 2
VGNC:9432
454738
Macaque
elongation factor Tu GTP binding domain containing 2
715512
Mouse
MGI:1336880
20624
Rat
RGD:1560116
287739
Dog
elongation factor Tu GTP binding domain containing 2
VGNC:40234
490935
Species
Name
OMA
EggNOG
Inparanoid
Chimp
elongation factor Tu GTP binding domain containing 2
Macaque
elongation factor Tu GTP binding domain containing 2
Mouse
Rat
Dog
elongation factor Tu GTP binding domain containing 2
Publication Statistics
PubMed Score 66.01
PubMed score by year
PubTator Score 29.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title