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Tbio
ACAP1
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

Protein Summary
Description
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000158762
  • ENSP00000158762
  • ENSG00000072818

Symbol
  • CENTB1
  • KIAA0050
  • CENTB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
tissue sample
0.69
gene perturbation
0.62
cell type or tissue
0.58
hub protein
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.82   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.82   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (61)
1 – 10 of 61
ARF6
Tbio
Family: Enzyme
Novelty: 0.00305495
Score: 0.983
Data Source: STRINGDB
CLTC
Tbio
Novelty: 0.00348813
Score: 0.94
Data Source: STRINGDB
SLC2A4
Tbio
Family: Transporter
Novelty: 0.00043859
Score: 0.936
Data Source: STRINGDB
PLD2
Tchem
Family: Enzyme
Novelty: 0.00368183
Score: 0.931
Data Source: STRINGDB
GULP1
Tbio
Novelty: 0.01241977
Score: 0.921
Data Source: STRINGDB
PLD1
Tchem
Family: Enzyme
Novelty: 0.00756297
Score: 0.921
Data Source: STRINGDB
ARF5
Tbio
Family: Enzyme
Novelty: 0.03428337
Score: 0.759
Data Source: STRINGDB
ANKRD10
Tdark
Novelty: 2
Score: 0.748
Data Source: STRINGDB
ANKRD46
Tbio
Novelty: 0.04505658
Score: 0.748
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.0000383
Score: 0.724
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.82

PubMed score by year
PubTator Score  13.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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