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Tbio
TNIP1
TNFAIP3-interacting protein 1

Protein Summary
Description
Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of G ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315050
  • ENSP00000317891
  • ENSG00000145901
  • ENST00000518977
  • ENSP00000430971
  • ENST00000520931
  • ENSP00000429891
  • ENST00000521591
  • ENSP00000430760
  • ENST00000522226
  • ENSP00000428187
  • ENST00000523200
  • ENSP00000431105
  • ENST00000523338
  • ENSP00000428243
  • ENST00000524280
  • ENSP00000429912
  • ENST00000610535
  • ENSP00000483944
  • ENST00000610874
  • ENSP00000484665

Symbol
  • KIAA0113
  • NAF1
  • VAN
  • NAF1
  • ABIN-1
  • nip40-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
biological process
0.87
phenotype
0.86
transcription factor perturbation
0.8
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.41   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.41   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
0
1.3
98.9
6
3
0
1.6
98.4
2
2
0
3.7
97.6
psoriasis vulgaris
2
1
0
1.8
95.7
5
5
0
1.2
86.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
98.9
0
1.6
98.4
0
3.7
97.6
psoriasis vulgaris
0
1.8
95.7
0
1.2
86.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNFAIP3 interacting protein 1
VGNC:4206
462197
Macaque
TNFAIP3 interacting protein 1
713124
Mouse
MGI:1926194
57783
Rat
RGD:1309380
363599
Dog
TNFAIP3 interacting protein 1
VGNC:47676
489178
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNFAIP3 interacting protein 1
Macaque
TNFAIP3 interacting protein 1
Mouse
Rat
Dog
TNFAIP3 interacting protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15025-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (538)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Ovarian tumor domain proteases
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Ovarian tumor domain proteases
Post-translational protein modification
Protein-Protein Interactions (100)
1 – 10 of 100
CRHBP
Tbio
Novelty: 0.00726484
p_int: 0.999999937
p_ni: 6.3e-8
Score: 0.261
Data Source: BioPlex,STRINGDB
ABI2
Tbio
Novelty: 0.02324355
p_int: 0.99999843
p_ni: 0.00000157
Data Source: BioPlex
IKBIP
Tbio
Family: Enzyme
Novelty: 0.18707639
p_int: 0.999997241
p_ni: 0.000002759
Score: 0.194
Data Source: BioPlex,STRINGDB
PIGT
Tbio
Family: Enzyme
Novelty: 0.02539879
p_int: 0.999957839
p_ni: 0.000042161
Data Source: BioPlex
GRAP2
Tbio
Novelty: 0.00503901
p_int: 0.999921754
p_ni: 0.000078246
Score: 0.196
Data Source: BioPlex,STRINGDB
OPTN
Tbio
Novelty: 0.00080427
p_int: 0.999881254
p_ni: 0.0000575
p_wrong: 0.000061245
Score: 0.476
Data Source: BioPlex,STRINGDB
SYNC
Tbio
Novelty: 0.04605223
p_int: 0.999860315
p_ni: 0.000139685
Data Source: BioPlex
SAMD4A
Tbio
Novelty: 0.04440962
p_int: 0.99984588
p_ni: 0.000154117
p_wrong: 3e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999514009
p_ni: 0.00048599
Data Source: BioPlex
HAO2
Tchem
Family: Enzyme
Novelty: 0.03029536
p_int: 0.994058647
p_ni: 0.005941351
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  90.41

PubMed score by year
PubTator Score  48.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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