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Tbio
NCAPD2
Condensin complex subunit 1

Protein Summary
Description
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315579
  • ENSP00000325017
  • ENSG00000010292

Symbol
  • CAPD2
  • CNAP1
  • KIAA0159
  • CNAP1
  • CAP-D2
  • MCPH21
  • hCAP-D2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.91
transcription factor binding site profile
0.89
disease perturbation
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.3   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.3   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (202)
ARPC1A
Tbio
Novelty:  0.07577807
p_int:  0.99997106
p_ni:  0.000028879
p_wrong:  6.1e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.999951506
p_ni:  0.000048494
Data Source:  BioPlex
PIP
Tbio
Novelty:  0.00208509
p_int:  0.996946753
p_ni:  0.003053247
Data Source:  BioPlex
GPR137B
Tbio
Novelty:  0.17325252
p_int:  0.992627772
p_ni:  0.007371979
p_wrong:  2.49e-7
Score:  0.219
Data Source:  BioPlex,STRINGDB
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.991426473
p_ni:  0.008573526
p_wrong:  1e-9
Data Source:  BioPlex
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.988909101
p_ni:  0.011090736
p_wrong:  1.63e-7
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.987686645
p_ni:  0.012313355
Data Source:  BioPlex
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.935668079
p_ni:  0.064331921
Data Source:  BioPlex
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.863685423
p_ni:  0.136314559
p_wrong:  1.8e-8
Data Source:  BioPlex
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.843737307
p_ni:  0.156134441
p_wrong:  0.000128252
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Condensation of Prometaphase Chromosomes
Reactome
M Phase
Reactome
Mitotic Prometaphase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Condensation of Prometaphase Chromosomes
M Phase
Mitotic Prometaphase
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
4
96
lymphocyte percentage of leukocytes
2
2
3
82.7
platelet crit
2
2
2
82.7
2
2
0
1.1
73.8
platelet count
2
2
2
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
96
lymphocyte percentage of leukocytes
3
82.7
platelet crit
2
82.7
0
1.1
73.8
platelet count
2
70.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
non-SMC condensin I complex subunit D2
VGNC:8495
747674
Macaque
non-SMC condensin I complex subunit D2
712834
Mouse
MGI:1915548
68298
Rat
RGD:1562596
362438
Dog
non-SMC condensin I complex subunit D2
VGNC:43639
477715
Species
Name
OMA
EggNOG
Inparanoid
Chimp
non-SMC condensin I complex subunit D2
Macaque
non-SMC condensin I complex subunit D2
Mouse
Rat
Dog
non-SMC condensin I complex subunit D2
Publication Statistics
PubMed Score 17.30
PubMed score by year
PubTator Score 13.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title