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Tbio
SART3
Squamous cell carcinoma antigen recognized by T-cells 3

Protein Summary
Description
U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:12032085). Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites (PubMed:14749385). May also function as a substrate-targeting factor for deubiquitinases like USP4 and USP15. Recruits USP4 to ubiquitinated PRPF3 within the U4/U5/U6 tri-snRNP complex, promoting PRPF3 deubiquitination and thereby regulating the spliceosome U4/U5/U6 tri-snRNP spliceosomal complex disassembly (PubMed:20595234). May also recruit the deubiquitinase USP15 to histone H2B and mediate histone deubiquitination, thereby regulating gene expression and/or DNA repair (PubMed:24526689). Ma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228284
  • ENSP00000228284
  • ENSG00000075856
  • ENST00000431469
  • ENSP00000414453
  • ENST00000546611
  • ENSP00000448554
  • ENST00000546728
  • ENSP00000449743

Symbol
  • KIAA0156
  • TIP110
  • P100
  • p110
  • DSAP1
  • TIP110
  • p110(nrb)
  • RP11-13G14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor binding site profile
0.91
disease perturbation
0.9
kinase perturbation
0.88
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.19   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.19   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (168)
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.999999999
p_ni:  1e-9
Score:  0.896
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.999999999
p_ni:  1e-9
Score:  0.534
Data Source:  BioPlex,STRINGDB
TUT1
Tbio
Family:  Enzyme
Novelty:  0.01436913
p_int:  0.99999995
p_ni:  5e-8
Score:  0.753
Data Source:  BioPlex,STRINGDB
RPS26P11
Tdark
p_int:  0.999999421
p_ni:  5.74e-7
p_wrong:  5e-9
Data Source:  BioPlex
PRPF31
Tbio
Novelty:  0.0105753
p_int:  0.999997533
p_ni:  0.000002467
Score:  0.963
Data Source:  BioPlex,STRINGDB
LSM6
Tbio
Novelty:  0.09507671
p_int:  0.999957463
p_ni:  0.000042537
Score:  0.938
Data Source:  BioPlex,STRINGDB
MEPCE
Tbio
Novelty:  0.05592081
p_int:  0.99994998
p_ni:  0.00005002
Score:  0.927
Data Source:  BioPlex,STRINGDB
PRPF4
Tchem
Novelty:  0.08229072
p_int:  0.999800223
p_ni:  0.000199777
Score:  0.892
Data Source:  BioPlex,STRINGDB
ZSCAN21
Tbio
Family:  TF
Novelty:  0.18025344
p_int:  0.999488563
p_ni:  0.000509985
p_wrong:  0.000001452
Data Source:  BioPlex
USP4
Tchem
Family:  Enzyme
Novelty:  0.01101075
p_int:  0.998182934
p_ni:  0.001817066
Score:  0.978
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
4
4
64.2
heel bone mineral density
2
1
2
44.2
reticulocyte count
2
1
2
11.9
reticulocyte measurement
1
1
1
8.2
optic disc size measurement
1
1
1
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
64.2
heel bone mineral density
2
44.2
reticulocyte count
2
11.9
reticulocyte measurement
1
8.2
optic disc size measurement
1
7.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
squamous cell carcinoma antigen recognized by T cells 3
VGNC:8528
467123
Macaque
squamous cell carcinoma antigen recognized by T-cells 3
705552
Mouse
MGI:1858230
53890
Rat
RGD:1311646
304582
Dog
squamous cell carcinoma antigen recognized by T-cells 3
486319
Species
Name
OMA
EggNOG
Inparanoid
Chimp
squamous cell carcinoma antigen recognized by T cells 3
Macaque
squamous cell carcinoma antigen recognized by T-cells 3
Mouse
Rat
Dog
squamous cell carcinoma antigen recognized by T-cells 3
Publication Statistics
PubMed Score 53.19
PubMed score by year
PubTator Score 138.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title