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Tbio
MORF4L2
Mortality factor 4-like protein 2

Protein Summary
Description
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360458
  • ENSP00000353643
  • ENSG00000123562
  • ENST00000422154
  • ENSP00000394417
  • ENST00000433176
  • ENSP00000415476
  • ENST00000441076
  • ENSP00000391969
  • ENST00000451301
  • ENSP00000410532

Symbol
  • KIAA0026
  • MRGX
  • MRGX
  • MORFL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.99
transcription factor perturbation
0.91
interacting protein
0.9
transcription factor
0.89


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.91   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.91   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
21
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
21
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mortality factor 4 like 2
VGNC:2694
465783
Macaque
mortality factor 4 like 2
697637
Mouse
MGI:1927167
56397
Rat
RGD:1359471
317413
Dog
mortality factor 4 like 2
VGNC:43320
481001
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mortality factor 4 like 2
Macaque
mortality factor 4 like 2
Mouse
Rat
Dog
mortality factor 4 like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15014-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (110)
1 – 10 of 110
MRGBP
Tbio
Novelty: 0.09537142
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
MORF4L1
Tbio
Family: Epigenetic
Novelty: 0.01696001
p_int: 1
Score: 0.984
Data Source: BioPlex,STRINGDB
EP400P1
Tdark
Novelty: 2.69614836
p_int: 0.999999999
p_ni: 1e-9
Score: 0.854
Data Source: BioPlex,STRINGDB
MRFAP1L1
Tdark
Novelty: 0.87470289
p_int: 0.999999989
p_ni: 1e-9
p_wrong: 1e-8
Score: 0.843
Data Source: BioPlex,STRINGDB
PALB2
Tbio
Novelty: 0.00320056
p_int: 0.999999968
p_ni: 3.2e-8
Score: 0.867
Data Source: BioPlex,STRINGDB
BRD8
Tbio
Family: Epigenetic
Novelty: 0.09769287
p_int: 0.999998961
p_ni: 0.000001039
Score: 0.99
Data Source: BioPlex,STRINGDB
ASH1L
Tbio
Family: Epigenetic
Novelty: 0.02897328
p_int: 0.999998505
p_ni: 0.000001495
Score: 0.67
Data Source: BioPlex,STRINGDB
EP400
Tbio
Novelty: 0.02013098
p_int: 0.999994409
p_ni: 0.000005591
Score: 0.981
Data Source: BioPlex,STRINGDB
PHF12
Tbio
Family: Epigenetic
Novelty: 0.00240295
p_int: 0.999988131
p_ni: 0.000011868
Score: 0.974
Data Source: BioPlex,STRINGDB
SATB2
Tbio
Family: TF
Novelty: 0.00405935
p_int: 0.999987635
p_ni: 0.000012356
p_wrong: 9e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  8.91

PubMed score by year
PubTator Score  6.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer