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Tbio
HERPUD1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Protein Summary
Description
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982). The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300302
  • ENSP00000300302
  • ENSG00000051108
  • ENST00000344114
  • ENSP00000340931
  • ENST00000379792
  • ENSP00000369118
  • ENST00000439977
  • ENSP00000409555

Symbol
  • HERP
  • KIAA0025
  • MIF1
  • SUP
  • HERP
  • Mif1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.98
biological process
0.95
transcription factor binding site profile
0.93
transcription factor perturbation
0.91
virus perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.95   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.95   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (55)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
53
73
182
2.7
100
apolipoprotein A 1 measurement
2
30
30
100
sleep duration
4
17
25
99.9
total cholesterol measurement
13
26
44
2.5
99.4
triglyceride measurement
17
20
42
2.9
99
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
182
2.7
100
apolipoprotein A 1 measurement
30
100
sleep duration
25
99.9
total cholesterol measurement
44
2.5
99.4
triglyceride measurement
42
2.9
99
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homocysteine inducible ER protein with ubiquitin like domain 1
VGNC:9083
454109
Macaque
homocysteine inducible ER protein with ubiquitin like domain 1
703210
Mouse
MGI:1927406
64209
Rat
RGD:620818
85430
Dog
homocysteine inducible ER protein with ubiquitin like domain 1
VGNC:41663
478116
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homocysteine inducible ER protein with ubiquitin like domain 1
Macaque
homocysteine inducible ER protein with ubiquitin like domain 1
Mouse
Rat
Dog
homocysteine inducible ER protein with ubiquitin like domain 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15011-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Metabolism of proteins
Reactome
PERK regulates gene expression
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Metabolism of proteins
PERK regulates gene expression
Unfolded Protein Response (UPR)
Gene Ontology Terms (18)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Protein-Protein Interactions (70)
1 – 10 of 70
CAPN15
Tbio
Novelty:  0.01046841
p_int:  0.999954222
p_ni:  0.000045778
Score:  0.537
Data Source:  BioPlex,STRINGDB
ATG9A
Tbio
Novelty:  0.01995033
p_int:  0.999520533
p_ni:  0.000008772
p_wrong:  0.000470696
Score:  0.187
Data Source:  BioPlex,STRINGDB
ATF4
Tbio
Family:  TF
Novelty:  0.00253408
Score:  0.96
Data Source:  STRINGDB
PKD2
Tchem
Family:  IC
Novelty:  0.00305329
Score:  0.901
Data Source:  STRINGDB
SYVN1
Tbio
Family:  Enzyme
Novelty:  0.02216474
Score:  0.875
Data Source:  STRINGDB
DERL2
Tbio
Novelty:  0.02479307
Score:  0.79
Data Source:  STRINGDB
EDEM1
Tbio
Family:  Enzyme
Novelty:  0.01157706
Score:  0.762
Data Source:  STRINGDB
PRKCSH
Tbio
Family:  Enzyme
Novelty:  0.00787916
Score:  0.752
Data Source:  STRINGDB
DNAJB9
Tbio
Novelty:  0.00536296
Score:  0.75
Data Source:  STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
Score:  0.736
Data Source:  STRINGDB
Publication Statistics
PubMed Score  183.95

PubMed score by year
PubTator Score  845.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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