Tbio PSMD6 26S proteasome non-ATPase regulatory subunit 6

Protein Summary

Description

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. This gene encodes a member of the protease subunit S10 family. The encoded protein is a subunit of the 26S proteasome which colocalizes with DNA damage foci and is involved in the ATP-dependent degradation of ubiquinated proteins. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q15008
• A8K2E0
• E9PHI9
• Q6UV22

Gene Name

• PSMD6

Ensembl ID

• ENST00000295901
• ENSP00000295901
• ENSG00000163636
• ENST00000394431
• ENSP00000377952
• ENST00000482510
• ENSP00000419227
• ENST00000492933
• ENSP00000418695

Symbol

• KIAA0107
• PFAAP4
• S10
• Rpn7
• p42A
• p44S10
• SGA-113M

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
biological process	0.98
hub protein	0.82
transcription factor binding site profile	0.75
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.36   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 262   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.36   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0