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Tbio
WTAP
Pre-mRNA-splicing regulator WTAP

Protein Summary
Description
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724). The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337387
  • ENSP00000336911
  • ENSG00000146457
  • ENST00000358372
  • ENSP00000351141
  • ENST00000621533
  • ENSP00000479438
  • ENST00000650096
  • ENSP00000497840

Symbol
  • KIAA0105
  • Mum2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
kinase perturbation
0.96
virus perturbation
0.88
disease perturbation
0.87
transcription factor perturbation
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.09   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.09   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WT1 associated protein
VGNC:14797
463110
Macaque
WT1 associated protein
702295
Mouse
MGI:1926395
60532
Rat
RGD:1563824
499020
Dog
WT1 associated protein
VGNC:54003
476259
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WT1 associated protein
Macaque
WT1 associated protein
Mouse
Rat
Dog
WT1 associated protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15007-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Gene Ontology Terms (12)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (86)
1 – 10 of 86
CBLL2
Tdark
Family: Enzyme
Novelty: 0.27990611
p_int: 0.998919128
p_ni: 0.001080872
Score: 0.918
Data Source: BioPlex,STRINGDB
IKZF1
Tbio
Family: TF
Novelty: 0.0016117
p_int: 0.945079659
p_ni: 0.054920341
Score: 0.246
Data Source: BioPlex,STRINGDB
ABRAXAS1
Tbio
Novelty: 0.07078408
p_int: 0.899636285
p_ni: 0.100363715
Score: 0.519
Data Source: BioPlex,STRINGDB
SH3BP5L
Tdark
Novelty: 1.7921497
p_int: 0.827659765
p_ni: 0.172340235
Score: 0.237
Data Source: BioPlex,STRINGDB
ZC3H13
Tbio
Novelty: 0.0990341
Score: 0.999
Data Source: STRINGDB
CBLL1
Tbio
Family: Enzyme
Novelty: 0.04070026
Score: 0.999
Data Source: STRINGDB
VIRMA
Tbio
Novelty: 0.05400878
Score: 0.999
Data Source: STRINGDB
METTL3
Tbio
Family: Enzyme
Novelty: 0.00420954
Score: 0.998
Data Source: Reactome,STRINGDB
METTL14
Tbio
Family: Enzyme
Novelty: 0.01377112
Score: 0.998
Data Source: Reactome,STRINGDB
RBM15
Tbio
Novelty: 0.00948292
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  64.09

PubMed score by year
PubTator Score  24.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer