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Tbio
EMC2
ER membrane protein complex subunit 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220853
  • ENSP00000220853
  • ENSG00000104412

Symbol
  • KIAA0103
  • TTC35
  • TTC35
  • KIAA0103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
disease perturbation
0.9
histone modification site profile
0.8
virus perturbation
0.79
cell type or tissue
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.6   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.6   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
1
2
2
76.7
2
2
1
2.2
75.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Alopecia
2
76.7
1
2.2
75.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ER membrane protein complex subunit 2
VGNC:882
472841
Macaque
ER membrane protein complex subunit 2
697878
Mouse
MGI:1913986
66736
Dog
ER membrane protein complex subunit 2
612810
Horse
ER membrane protein complex subunit 2
VGNC:17553
100063908
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ER membrane protein complex subunit 2
Macaque
ER membrane protein complex subunit 2
Mouse
Dog
ER membrane protein complex subunit 2
Horse
ER membrane protein complex subunit 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q15006-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (55)
1 – 10 of 55
EMC9
Tdark
Novelty:  0.52441743
p_int:  0.999999998
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
EMC3
Tbio
Novelty:  0.01113829
p_int:  0.999999976
p_ni:  2.4e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
EMC7
Tdark
Novelty:  0.28771768
p_int:  0.999996396
p_ni:  0.000003604
Score:  0.993
Data Source:  BioPlex,STRINGDB
EMC8
Tdark
Novelty:  0.2452967
p_int:  0.999970239
p_ni:  0.000029646
p_wrong:  1.15e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
EMC10
Tbio
Novelty:  0.04986528
p_int:  0.998384283
p_ni:  0.001615001
p_wrong:  7.16e-7
Score:  0.994
Data Source:  BioPlex,STRINGDB
EMC4
Tbio
Novelty:  0.12174476
p_int:  0.994784699
p_ni:  0.005196659
p_wrong:  0.000018643
Score:  0.999
Data Source:  BioPlex,STRINGDB
MMGT1
Tdark
Novelty:  0.20333677
p_int:  0.981564374
p_ni:  0.018435627
Score:  0.993
Data Source:  BioPlex,STRINGDB
EMC1
Tbio
Novelty:  0.05360812
p_int:  0.966595661
p_ni:  0.033404339
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.956093888
p_ni:  0.043906112
Score:  0.689
Data Source:  BioPlex,STRINGDB
EMC6
Tbio
Novelty:  0.18299013
p_int:  0.953181615
p_ni:  0.000093162
p_wrong:  0.046725224
Score:  0.998
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.60

PubMed score by year
PubTator Score  2.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer