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Tdark
SPCS2
Signal peptidase complex subunit 2

Protein Classes
Protein Summary
Description
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263672
  • ENSP00000263672
  • ENSG00000118363

Symbol
  • KIAA0102
  • SPC25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.97
co-expressed gene
0.82
small molecule perturbation
0.79
gene perturbation
0.74


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.06   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.06   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
signal peptidase complex subunit 2
VGNC:997
748664
Macaque
signal peptidase complex subunit 2
694179
Mouse
MGI:1913874
66624
Rat
RGD:1311253
293142
Dog
signal peptidase complex subunit 2
VGNC:46725
404016
Species
Name
OMA
EggNOG
Inparanoid
Chimp
signal peptidase complex subunit 2
Macaque
signal peptidase complex subunit 2
Mouse
Rat
Dog
signal peptidase complex subunit 2
Pathways (10)
Incretin synthesis, secretion, and inactivation (R-HSA-400508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Incretin synthesis, secretion, and inactivation
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Reactome
SRP-dependent cotranslational protein targeting to membrane
Reactome
Synthesis, secretion, and deacylation of Ghrelin
Name
Explore in Pharos
Explore in Source
Incretin synthesis, secretion, and inactivation
Metabolism of proteins
Peptide hormone metabolism
SRP-dependent cotranslational protein targeting to membrane
Synthesis, secretion, and deacylation of Ghrelin
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (187)
1 – 10 of 187
SEC11C
Tdark
Family: Enzyme
Novelty: 0.19577003
p_int: 0.999993059
p_ni: 0.000006941
Score: 0.998
Data Source: BioPlex,STRINGDB
SPCS3
Tbio
Family: Enzyme
Novelty: 0.13677259
p_int: 0.999986063
p_ni: 0.000013938
Score: 0.993
Data Source: BioPlex,STRINGDB
SEC11A
Tbio
Family: Enzyme
Novelty: 0.05764568
p_int: 0.998197266
p_ni: 0.001802734
Score: 0.992
Data Source: BioPlex,STRINGDB
GPC4
Tbio
Novelty: 0.01319626
p_int: 0.990302956
p_ni: 0.009697044
Data Source: BioPlex
ARSK
Tbio
Family: Enzyme
Novelty: 0.11486213
p_int: 0.974771299
p_ni: 0.025228701
Data Source: BioPlex
PVRIG
Tdark
Novelty: 0.28920924
p_int: 0.968457245
p_ni: 0.031542754
p_wrong: 1e-9
Score: 0.527
Data Source: BioPlex,STRINGDB
FBXL14
Tbio
Novelty: 0.21211079
p_int: 0.963077319
p_ni: 0.036922681
Score: 0.161
Data Source: BioPlex,STRINGDB
TM2D3
Tbio
Novelty: 0.09408834
p_int: 0.962585399
p_ni: 0.037414601
Score: 0.54
Data Source: BioPlex,STRINGDB
GPC1
Tbio
Novelty: 0.00293087
p_int: 0.938053954
p_ni: 0.061946046
Score: 0.186
Data Source: BioPlex,STRINGDB
ALPL
Tchem
Family: Enzyme
Novelty: 0.00152281
p_int: 0.935471853
p_ni: 0.064528147
Score: 0.823
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  4.06

PubMed score by year
PubTator Score  0.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer