Tbio PCLAF PCNA-associated factor

Protein Summary

Description

PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.

Uniprot Accession IDs

• Q15004
• A6NNU5
• A8K3Y3
• G9G694
• G9G696

Gene Name

• PCLAF

Ensembl ID

• ENST00000300035
• ENSP00000300035
• ENSG00000166803
• ENST00000380258
• ENSP00000369608

Symbol

• KIAA0101
• NS5ATP9
• PAF
• L5
• PAF
• OEATC
• PAF15
• OEATC1
• p15PAF
• NS5ATP9
• OEATC-1
• p15/PAF
• KIAA0101
• p15(PAF)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.68   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 203   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 424.68   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0