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Tbio
PCLAF
PCNA-associated factor

Protein Summary
Description
PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300035
  • ENSP00000300035
  • ENSG00000166803
  • ENST00000380258
  • ENSP00000369608

Symbol
  • KIAA0101
  • NS5ATP9
  • PAF
  • L5
  • PAF
  • OEATC
  • PAF15
  • OEATC1
  • p15PAF
  • NS5ATP9
  • OEATC-1
  • p15/PAF
  • KIAA0101
  • p15(PAF)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.18   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 358.18   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
81.4
neutrophil count
2
1
2
79.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
81.4
neutrophil count
2
79.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PCNA clamp associated factor
VGNC:1923
100614685
Macaque
PCNA clamp associated factor
100423080
Mouse
MGI:1915276
68026
Rat
RGD:1303041
300795
Horse
PCNA clamp associated factor
100053775
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PCNA clamp associated factor
Macaque
PCNA clamp associated factor
Mouse
Rat
Horse
PCNA clamp associated factor
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q15004-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Reactome
Termination of translesion DNA synthesis
Reactome
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Repair
Termination of translesion DNA synthesis
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (236)
1 – 10 of 236
PCNA
Tchem
Novelty: 0.03909539
p_int: 0.999594644
p_ni: 0.000405356
Score: 0.997
Data Source: BioPlex,STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
p_int: 0.986101281
p_ni: 0.013855983
p_wrong: 0.000042736
Score: 0.239
Data Source: BioPlex,STRINGDB
FANCM
Tbio
Novelty: 0.01122278
p_int: 0.970024997
p_ni: 0.029975003
Score: 0.893
Data Source: BioPlex,STRINGDB
RFC4
Tbio
Novelty: 0.03232586
Score: 0.975
Data Source: STRINGDB
POLE2
Tbio
Family: Enzyme
Novelty: 0.03129531
Score: 0.965
Data Source: STRINGDB
TOP2A
Tclin
Family: Enzyme
Novelty: 0.00122788
Score: 0.961
Data Source: STRINGDB
CCNA2
Tchem
Novelty: 0.00049887
Score: 0.956
Data Source: STRINGDB
CDC20
Tbio
Novelty: 0.00197887
Score: 0.955
Data Source: STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.952
Data Source: STRINGDB
UBE2C
Tbio
Novelty: 0.00731185
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  358.18

PubMed score by year
PubTator Score  819.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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