Tbio NAA25 N-alpha-acetyltransferase 25, NatB auxiliary subunit

Protein Summary

Description

Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression. This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]

Uniprot Accession IDs

• Q14CX7
• A0JLU7
• Q6MZH1
• Q7Z4N6
• Q9H911

Gene Name

• NAA25

Ensembl ID

• ENST00000261745
• ENSP00000261745
• ENSG00000111300

Symbol

• C12orf30
• MDM20
• NAP1
• NAP1
• MDM20
• C12orf30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.76
transcription factor binding site profile	0.73
microRNA	0.68
histone modification site profile	0.66
hub protein	0.63

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / N-alpha-acetyltransferase 25, Natb Auxiliary Subunit

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / N-alpha-acetyltransferase 25, Natb Auxiliary Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.43   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.43   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0