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Tbio
KRT72
Keratin, type II cytoskeletal 72

Protein Summary
Description
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. The type II keratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This gene encodes a type II keratin that is specifically expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q12-q13. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293745
  • ENSP00000293745
  • ENSG00000170486
  • ENST00000354310
  • ENSP00000346269
  • ENST00000537672
  • ENSP00000441160

Symbol
  • K6IRS2
  • KB35
  • KRT6
  • KRT6IRS2
  • KRT6
  • K6irs
  • K6IRS2
  • KRT6IRS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.61
cell line
0.59
cellular component
0.58
chemical
0.41
protein domain
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.05   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.05   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
KRT73
Tdark
Novelty:  0.36334003
Score:  0.955
Data Source:  STRINGDB
KRT17
Tbio
Novelty:  0.00278761
Score:  0.951
Data Source:  STRINGDB
KRT16
Tbio
Novelty:  0.00503235
Score:  0.938
Data Source:  STRINGDB
KRT20
Tbio
Novelty:  0.00132004
Score:  0.938
Data Source:  STRINGDB
KRT14
Tbio
Novelty:  0.00088743
Score:  0.936
Data Source:  STRINGDB
KRT32
Tdark
Novelty:  1.12077627
Score:  0.933
Data Source:  STRINGDB
KRT18
Tbio
Novelty:  0.00069055
Score:  0.933
Data Source:  STRINGDB
KRT9
Tbio
Novelty:  0.00787691
Score:  0.932
Data Source:  STRINGDB
KRT27
Tdark
Novelty:  0.34729004
Score:  0.932
Data Source:  STRINGDB
KRT15
Tbio
Novelty:  0.00351898
Score:  0.931
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
keratinocyte carcinoma
1
2
0
1.1
90.6
4
1
1
1.2
81.2
balding measurement
1
2
2
72.5
non-melanoma skin carcinoma
1
1
0
1.3
54.4
plasminogen activator inhibitor 1 measurement
1
1
0
590.4
34.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
keratinocyte carcinoma
0
1.1
90.6
1
1.2
81.2
balding measurement
2
72.5
non-melanoma skin carcinoma
0
1.3
54.4
plasminogen activator inhibitor 1 measurement
0
590.4
34.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 72
VGNC:14413
466993
Mouse
MGI:2146034
105866
Rat
RGD:1303216
406227
Dog
keratin 72
VGNC:42530
486520
Horse
keratin 72
VGNC:52403
100061693
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 72
Mouse
Rat
Dog
keratin 72
Horse
keratin 72
Publication Statistics
PubMed Score 12.05
PubMed score by year
PubTator Score 13.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title