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Tbio
FRMPD4
FERM and PDZ domain-containing protein 4

Protein Summary
Description
Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate. This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380682
  • ENSP00000370057
  • ENSG00000169933

Symbol
  • KIAA0316
  • PDZD10
  • PDZK10
  • MRX104
  • PDZD10
  • PDZK10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
protein domain
0.92
microRNA
0.63
cell line
0.59
interacting protein
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.02   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.02   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (57)
1 – 10 of 57
GPSM2
Tbio
Novelty:  0.00941766
Score:  0.845
Data Source:  STRINGDB
CEND1
Tbio
Novelty:  0.04549072
Score:  0.73
Data Source:  STRINGDB
TSPAN6
Tbio
Novelty:  0.11515803
Score:  0.68
Data Source:  STRINGDB
RGS8
Tchem
Novelty:  0.03314557
Score:  0.656
Data Source:  STRINGDB
CNKSR2
Tbio
Family:  Enzyme
Novelty:  0.05451075
Score:  0.651
Data Source:  STRINGDB
SEZ6L2
Tbio
Novelty:  0.02623263
Score:  0.649
Data Source:  STRINGDB
DLGAP3
Tbio
Novelty:  0.02019435
Score:  0.614
Data Source:  STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.612
Data Source:  STRINGDB
EFCAB12
Tdark
Novelty:  4.36260623
Score:  0.591
Data Source:  STRINGDB
KLHL15
Tbio
Novelty:  0.54712519
Score:  0.591
Data Source:  STRINGDB
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FERM and PDZ domain containing 4
473520
Macaque
FERM and PDZ domain containing 4
710334
Mouse
MGI:3042378
333605
Rat
RGD:1566031
302656
Dog
FERM and PDZ domain containing 4
VGNC:54142
611238
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FERM and PDZ domain containing 4
Macaque
FERM and PDZ domain containing 4
Mouse
Rat
Dog
FERM and PDZ domain containing 4
Publication Statistics
PubMed Score 5.02
PubMed score by year
PubTator Score 4.36
PubTator score by year