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Tbio
ARHGAP19
Rho GTPase-activating protein 19

Protein Summary
Description
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Members of the ARHGAP family, such as ARHGAP19, encode negative regulators of Rho GTPases (see RHOA; MIM 165390), which are involved in cell migration, proliferation, and differentiation, actin remodeling, and G1 cell cycle progression (Lv et al., 2007 [PubMed 17454002]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358308
  • ENSP00000351058
  • ENSG00000213390
  • ENST00000358531
  • ENSP00000351333
  • ENST00000371027
  • ENSP00000360066
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
microRNA
0.78
histone modification site profile
0.74
kinase perturbation
0.71
transcription factor binding site profile
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.07   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.07   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
1
1
46.9
eosinophil count
1
1
1
18
1
1
0
1.1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
46.9
eosinophil count
1
18
0
1.1
5.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1918335
71085
Dog
Rho GTPase activating protein 19
477784
Cow
Rho GTPase activating protein 19
526945
Opossum
Rho GTPase activating protein 19
100022266
Chicken
Rho GTPase activating protein 19
CGNC:52062
423846
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
Rho GTPase activating protein 19
Cow
Rho GTPase activating protein 19
Opossum
Rho GTPase activating protein 19
Chicken
Rho GTPase activating protein 19
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14CB8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (41)
1 – 10 of 41
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.999999998
p_ni: 1e-9
Data Source: BioPlex
FHIT
Tchem
Family: Enzyme
Novelty: 0.0012803
p_int: 0.999476738
p_ni: 0.000523262
Score: 0.309
Data Source: BioPlex,STRINGDB
IKZF5
Tbio
Family: TF
Novelty: 0.36596327
p_int: 0.999451568
p_ni: 0.000022409
p_wrong: 0.000526023
Score: 0.469
Data Source: BioPlex,STRINGDB
DCAF16
Tdark
Novelty: 0.35666992
p_int: 0.993460852
p_ni: 0.004583047
p_wrong: 0.001956101
Score: 0.158
Data Source: BioPlex,STRINGDB
RNF41
Tbio
Family: Enzyme
Novelty: 0.01953473
p_int: 0.991581892
p_ni: 0.007643124
p_wrong: 0.000774983
Data Source: BioPlex
TDRKH
Tbio
Family: Epigenetic
Novelty: 0.0875409
p_int: 0.956646497
p_ni: 0.043353503
Score: 0.54
Data Source: BioPlex,STRINGDB
LRP2
Tbio
Novelty: 0.00143258
p_int: 0.863578159
p_ni: 0.136421841
Score: 0.183
Data Source: BioPlex,STRINGDB
ERBIN
Tbio
Novelty: 0.01419561
p_int: 0.791974069
p_ni: 0.208025931
Score: 0.175
Data Source: BioPlex,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.952
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.07

PubMed score by year
PubTator Score  2.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer