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Tbio
SHPRH
E3 ubiquitin-protein ligase SHPRH

Protein Summary
Description
E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275233
  • ENSP00000275233
  • ENSG00000146414
  • ENST00000367505
  • ENSP00000356475
  • ENST00000438092
  • ENSP00000412797
  • ENST00000519632
  • ENSP00000430528

Symbol
  • KIAA2023
  • bA545I5.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
histone modification site profile
0.79
cell type or tissue
0.63
transcription factor binding site profile
0.62


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.71   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 233   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.71   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 233   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SNF2 histone linker PHD RING helicase
VGNC:8563
472146
Macaque
SNF2 histone linker PHD RING helicase
699114
Mouse
MGI:1917581
268281
Rat
RGD:1310342
308282
Dog
SNF2 histone linker PHD RING helicase
VGNC:49029
476233
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SNF2 histone linker PHD RING helicase
Macaque
SNF2 histone linker PHD RING helicase
Mouse
Rat
Dog
SNF2 histone linker PHD RING helicase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q149N8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Gene Ontology Terms (14)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (103)
1 – 10 of 103
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.999998088
p_ni: 0.000001912
Score: 0.672
Data Source: BioPlex,STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
p_int: 0.887843964
p_ni: 0.112156036
Score: 0.195
Data Source: BioPlex,STRINGDB
UBE2N
Tbio
Novelty: 0.00620946
Score: 0.989
Data Source: Reactome,STRINGDB
UBE2V2
Tbio
Novelty: 0.01112479
Score: 0.988
Data Source: Reactome,STRINGDB
RAD18
Tbio
Family: Enzyme
Novelty: 0.00519213
Score: 0.984
Data Source: Reactome,STRINGDB
UBE2B
Tbio
Novelty: 0.01578275
Score: 0.97
Data Source: Reactome,STRINGDB
PCNA
Tchem
Novelty: 0.03909539
Score: 0.952
Data Source: Reactome,STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.911
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.911
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.71

PubMed score by year
PubTator Score  8.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer