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Tbio
CUL7
Cullin-7

Protein Summary
Description
Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265348
  • ENSP00000265348
  • ENSG00000044090
  • ENST00000535468
  • ENSP00000438788

Symbol
  • KIAA0076
  • 3M1
  • CUL-7
  • KIAA0076
  • dJ20C7.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
protein domain
0.92
transcription factor binding site profile
0.79
phenotype
0.63
cell line
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.46   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.46   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
3
3
92.7
apolipoprotein B measurement
2
3
3
86.8
high density lipoprotein cholesterol measurement
2
2
3
79.6
bilirubin measurement
1
1
1
67.3
homocysteine measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
3
92.7
apolipoprotein B measurement
3
86.8
high density lipoprotein cholesterol measurement
3
79.6
bilirubin measurement
1
67.3
homocysteine measurement
1
47.7
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cullin 7
VGNC:2679
472011
Macaque
cullin 7
699545
Mouse
MGI:1913765
66515
Rat
RGD:1587048
680835
Horse
cullin 7
VGNC:16972
100067262
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cullin 7
Macaque
cullin 7
Mouse
Rat
Horse
cullin 7
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14999-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
IRE1alpha activates chaperones
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
IRE1alpha activates chaperones
Immune System
Gene Ontology Terms (23)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (327)
1 – 10 of 327
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.999999796
p_ni:  2.04e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999999361
p_ni:  6.4e-7
Score:  0.981
Data Source:  BioPlex,STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
p_int:  0.999998204
p_ni:  0.000001796
Score:  0.776
Data Source:  BioPlex,STRINGDB
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.999992926
p_ni:  0.000007075
Data Source:  BioPlex
TP53
Tchem
Family:  TF
Novelty:  0.00001907
p_int:  0.999991499
p_ni:  0.000008501
Score:  0.661
Data Source:  BioPlex,STRINGDB
ZNF669
Tdark
Family:  TF
Novelty:  2.09725685
p_int:  0.999979036
p_ni:  0.000020964
Data Source:  BioPlex
CASQ2
Tbio
Novelty:  0.00775794
p_int:  0.999956174
p_ni:  0.000043826
Data Source:  BioPlex
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999955786
p_ni:  0.000044214
Score:  0.929
Data Source:  BioPlex,STRINGDB
DGKG
Tbio
Family:  Enzyme
Novelty:  0.03666646
p_int:  0.999904325
p_ni:  0.000095675
Data Source:  BioPlex
ZKSCAN8
Tbio
Family:  TF
Novelty:  0.17881042
p_int:  0.999694436
p_ni:  0.000305565
Data Source:  BioPlex
Publication Statistics
PubMed Score  58.46

PubMed score by year
PubTator Score  34.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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