Tbio PSME4 Proteasome activator complex subunit 4

Protein Summary

Description

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Uniprot Accession IDs

• Q14997
• Q1XBG4
• Q1XBG5
• Q1XBG6
• Q2M1Z0
• Q6IPR2
• Q86XF8

Gene Name

• PSME4

Ensembl ID

• ENST00000404125
• ENSP00000384211
• ENSG00000068878

Symbol

• KIAA0077
• PA200

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	1
biological process	0.99
kinase perturbation	0.99
disease perturbation	0.98
transcription factor perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.19   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 91   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.19   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0