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Tbio
PSME4
Proteasome activator complex subunit 4

Protein Summary
Description
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404125
  • ENSP00000384211
  • ENSG00000068878

Symbol
  • KIAA0077
  • PA200
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
1
biological process
0.99
kinase perturbation
0.99
disease perturbation
0.98
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.66   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.66   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
2
2
93.3
body mass index
1
1
1
44.1
grip strength measurement
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
93.3
body mass index
1
44.1
grip strength measurement
1
16.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proteasome activator subunit 4
VGNC:351
459229
Macaque
proteasome activator subunit 4
716580
Mouse
MGI:2143994
103554
Rat
RGD:1591971
498433
Dog
proteasome activator subunit 4
VGNC:45119
474594
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proteasome activator subunit 4
Macaque
proteasome activator subunit 4
Mouse
Rat
Dog
proteasome activator subunit 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q14997-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (138)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 137
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Securin
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (282)
1 – 10 of 282
PSMB1
Tclin
Family: Enzyme
Novelty: 0.0255917
p_int: 0.999999829
p_ni: 1.71e-7
Score: 0.993
Data Source: BioPlex,STRINGDB
PSMA5
Tbio
Family: Enzyme
Novelty: 0.03862668
p_int: 0.9999993
p_ni: 7e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
PSMB2
Tclin
Family: Enzyme
Novelty: 0.06714761
p_int: 0.999999247
p_ni: 7.53e-7
Score: 0.996
Data Source: BioPlex,STRINGDB
PSMB9
Tchem
Family: Enzyme
Novelty: 0.0016249
p_int: 0.999999186
p_ni: 8.14e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
PSMB7
Tbio
Family: Enzyme
Novelty: 0.06547657
p_int: 0.999998607
p_ni: 0.000001393
Score: 0.993
Data Source: BioPlex,STRINGDB
PSMB4
Tbio
Family: Enzyme
Novelty: 0.0376233
p_int: 0.999992478
p_ni: 0.000007522
Score: 0.997
Data Source: BioPlex,STRINGDB
PSMA1
Tclin
Family: Enzyme
Novelty: 0.013722
p_int: 0.999984771
p_ni: 0.000015229
Score: 0.997
Data Source: BioPlex,STRINGDB
PSMB3
Tbio
Family: Enzyme
Novelty: 0.12791198
p_int: 0.999983003
p_ni: 0.000016997
Score: 0.988
Data Source: BioPlex,STRINGDB
GTF3C4
Tdark
Family: Epigenetic
Novelty: 0.28198123
p_int: 0.99993379
p_ni: 0.00006621
Data Source: BioPlex
LYPD6B
Tdark
Novelty: 0.1409054
p_int: 0.99936513
p_ni: 0.00063487
Data Source: BioPlex
Publication Statistics
PubMed Score  83.66

PubMed score by year
PubTator Score  20.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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