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Tchem
NR1I3
Nuclear receptor subfamily 1 group I member 3

Protein Summary
Description
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign comp ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367979
  • ENSP00000356958
  • ENSG00000143257
  • ENST00000367980
  • ENSP00000356959
  • ENST00000367981
  • ENSP00000356960
  • ENST00000367982
  • ENSP00000356961
  • ENST00000367983
  • ENSP00000356962
  • ENST00000367984
  • ENSP00000356963
  • ENST00000367985
  • ENSP00000356965
  • ENST00000412844
  • ENSP00000399361
  • ENST00000428574
  • ENSP00000412672
  • ENST00000437437
  • ENSP00000407446
  • ENST00000442691
  • ENSP00000406493
  • ENST00000504010
  • ENSP00000424345
  • ENST00000505005
  • ENSP00000424934
  • ENST00000508740
  • ENSP00000423666
  • ENST00000511676
  • ENSP00000427175
  • ENST00000512372
  • ENSP00000425417

Symbol
  • CAR
  • CAR
  • CAR1
  • MB67
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
molecular function
0.97
protein domain
0.85
tissue sample
0.65
biological process
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.23   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 409   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 325.23   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
68.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
68.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 1 group I member 3
VGNC:6922
458014
Macaque
nuclear receptor subfamily 1 group I member 3
574249
Mouse
MGI:1346307
12355
Rat
RGD:621400
65035
Dog
nuclear receptor subfamily 1 group I member 3
VGNC:43945
488653
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 1 group I member 3
Macaque
nuclear receptor subfamily 1 group I member 3
Mouse
Rat
Dog
nuclear receptor subfamily 1 group I member 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14994-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Gene Ontology Terms (26)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (98)
1 – 10 of 98
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
p_int: 0.999972998
p_ni: 0.000026824
p_wrong: 1.78e-7
Score: 0.905
Data Source: BioPlex,STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
p_int: 0.998136896
p_ni: 0.001863104
Score: 0.857
Data Source: BioPlex,STRINGDB
MED4
Tbio
Family: Enzyme
Novelty: 0.01200585
p_int: 0.993144812
p_ni: 0.006855188
Score: 0.603
Data Source: BioPlex,STRINGDB
NCOA2
Tbio
Novelty: 0.00510052
p_int: 0.991722029
p_ni: 0.008275853
p_wrong: 0.000002118
Score: 0.827
Data Source: BioPlex,STRINGDB
MED14
Tbio
Family: Enzyme
Novelty: 0.01741917
p_int: 0.985436707
p_ni: 0.014563293
Score: 0.69
Data Source: BioPlex,STRINGDB
MED23
Tbio
Family: Enzyme
Novelty: 0.02860043
p_int: 0.949504066
p_ni: 0.050495934
Score: 0.616
Data Source: BioPlex,STRINGDB
PPM1B
Tchem
Family: Enzyme
Novelty: 0.02370446
p_int: 0.921987927
p_ni: 0.078012073
Score: 0.22
Data Source: BioPlex,STRINGDB
MED17
Tbio
Family: Enzyme
Novelty: 0.02984503
p_int: 0.912170426
p_ni: 0.087829572
p_wrong: 2e-9
Score: 0.554
Data Source: BioPlex,STRINGDB
MED13
Tbio
Family: Enzyme
Novelty: 0.02090708
p_int: 0.877172988
p_ni: 0.122827002
p_wrong: 1e-8
Score: 0.598
Data Source: BioPlex,STRINGDB
MED24
Tbio
Family: Enzyme
Novelty: 0.05466084
p_int: 0.822629976
p_ni: 0.177370024
Score: 0.641
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  325.23

PubMed score by year
PubTator Score  525.06

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer