Tbio COL19A1 Collagen alpha-1(XIX) chain

Protein Summary

Description

May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14993
• Q00559
• Q05850
• Q12885
• Q13676
• Q14DH1
• Q5JUF0
• Q5T424
• Q9H572
• Q9NPZ2
• Q9NQP2

Gene Name

• COL19A1

Ensembl ID

• ENST00000620364
• ENSP00000480474
• ENSG00000082293

Symbol

• COL9A1L
• D6S228E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
microRNA	0.91
gene perturbation	0.76
disease perturbation	0.68
trait	0.61

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.2   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 183   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.2   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (7)

Reactome (6)

PathwayCommons (1)

Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Collagen biosynthesis and modifying enzymes	67 targets	R-HSA-1650814
Reactome	Collagen chain trimerization	44 targets	R-HSA-8948216
Reactome	Collagen degradation	40 targets	R-HSA-1442490
Reactome	Collagen formation	90 targets	R-HSA-1474290
Reactome	Degradation of the extracellular matrix	111 targets	R-HSA-1474228

Name	Explore in Pharos	Explore in Source
Collagen biosynthesis and modifying enzymes	67 targets	R-HSA-1650814
Collagen chain trimerization	44 targets	R-HSA-8948216
Collagen degradation	40 targets	R-HSA-1442490
Collagen formation	90 targets	R-HSA-1474290
Degradation of the extracellular matrix	111 targets	R-HSA-1474228

Gene Ontology Terms (14)

Functions (2)

Components (5)

Processes (7)

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1 – 2 of 2

GO Term	Evidence	Assigned by
extracellular matrix structural constituent	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein binding, bridging	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (70)

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1 – 10 of 70

• See Interactions on String-DB

COL12A1

Tbio

Novelty: 0.03812985

Score: 0.932

Data Source: STRINGDB

COL21A1

Tbio

Novelty: 0.19225289

Score: 0.929

Data Source: STRINGDB

COL4A4

Tbio

Novelty: 0.01044051

Score: 0.925

Data Source: STRINGDB

COL9A1

Tbio

Novelty: 0.02281721

Score: 0.924

Data Source: STRINGDB

COL18A1

Tbio

Novelty: 0.00063031

Score: 0.922

Data Source: STRINGDB

COL15A1

Tbio

Novelty: 0.0632315

Score: 0.921

Data Source: STRINGDB

COL4A6

Tbio

Novelty: 0.03225517

Score: 0.92

Data Source: STRINGDB

COL11A1

Tbio

Novelty: 0.00813892

Score: 0.919

Data Source: STRINGDB

COL11A2

Tbio

Novelty: 0.01141248

Score: 0.917

Data Source: STRINGDB

COL4A1

Tbio

Novelty: 0.00485546

Score: 0.917

Data Source: STRINGDB

Publication Statistics

PubMed Score  6.20

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PubTator Score  3.06

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Cell adhesion
Collagen
Complete proteome
Developmental protein
Differentiation
Disulfide bond
Extracellular matrix
Hydroxylation
Myogenesis
Polymorphism

GWAS Trait Find Similar Targets

wellbeing measurement

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
digestive/alimentary phenotype
growth/size/body region phenotype
integument phenotype
mortality/aging
muscle phenotype