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Tbio
COL19A1
Collagen alpha-1(XIX) chain

Protein Summary
Description
May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
microRNA
0.91
gene perturbation
0.76
disease perturbation
0.68
trait
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.2   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.2   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (7)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

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Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen degradation
Reactome
Collagen formation
Reactome
Degradation of the extracellular matrix
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen degradation
Collagen formation
Degradation of the extracellular matrix
Protein-Protein Interactions (70)
1 – 10 of 70
COL12A1
Tbio
Novelty: 0.03812985
Score: 0.932
Data Source: STRINGDB
COL21A1
Tbio
Novelty: 0.19225289
Score: 0.929
Data Source: STRINGDB
COL4A4
Tbio
Novelty: 0.01044051
Score: 0.925
Data Source: STRINGDB
COL9A1
Tbio
Novelty: 0.02281721
Score: 0.924
Data Source: STRINGDB
COL18A1
Tbio
Novelty: 0.00063031
Score: 0.922
Data Source: STRINGDB
COL15A1
Tbio
Novelty: 0.0632315
Score: 0.921
Data Source: STRINGDB
COL4A6
Tbio
Novelty: 0.03225517
Score: 0.92
Data Source: STRINGDB
COL11A1
Tbio
Novelty: 0.00813892
Score: 0.919
Data Source: STRINGDB
COL11A2
Tbio
Novelty: 0.01141248
Score: 0.917
Data Source: STRINGDB
COL4A1
Tbio
Novelty: 0.00485546
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.20

PubMed score by year
PubTator Score  3.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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