COL19A1
Collagen alpha-1(XIX) chain
Protein Summary
May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008]
- ENST00000620364
- ENSP00000480474
- ENSG00000082293
- COL9A1L
- D6S228E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
microRNA | 0.91 | ||
gene perturbation | 0.76 | ||
disease perturbation | 0.68 | ||
trait | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.96 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 183 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.96 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 183 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (70)
Nearest Tclin Targets
Pathways (7)
Reactome (6)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Reactome | Collagen chain trimerization | ||||
Reactome | Collagen degradation | ||||
Reactome | Collagen formation | ||||
Reactome | Degradation of the extracellular matrix | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Collagen biosynthesis and modifying enzymes | ||||
Collagen chain trimerization | ||||
Collagen degradation | ||||
Collagen formation | ||||
Degradation of the extracellular matrix | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (2)
Components (5)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 47.7 | |||||
liver fat measurement | 1 | 1 | 1 | 31.4 | |||||
wellbeing measurement | 1 | 1 | 1 | 15.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 1 | 47.7 | |||||
liver fat measurement | 1 | 31.4 | |||||
wellbeing measurement | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | collagen type XIX alpha 1 chain | 716948 | ||||||
Mouse | MGI:1095415 | 12823 | ||||||
Rat | RGD:1308920 | 367236 | ||||||
Dog | collagen type XIX alpha 1 chain | VGNC:39463 | 481872 | |||||
Horse | collagen type XIX alpha 1 chain | VGNC:16729 | 100070855 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | collagen type XIX alpha 1 chain | |||||
Mouse | ||||||
Rat | ||||||
Dog | collagen type XIX alpha 1 chain | |||||
Horse | collagen type XIX alpha 1 chain | |||||
Publication Statistics
PubMed Score 8.96
PubMed score by year
PubTator Score 3.06
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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