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Tbio
COL19A1
Collagen alpha-1(XIX) chain

Protein Summary
Description
May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle. This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
microRNA
0.91
gene perturbation
0.76
disease perturbation
0.68
trait
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.96   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.96   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (70)
1 – 10 of 70
COL12A1
Tbio
Novelty:  0.0239421
Score:  0.932
Data Source:  STRINGDB
COL21A1
Tbio
Novelty:  0.1583142
Score:  0.929
Data Source:  STRINGDB
COL4A4
Tbio
Novelty:  0.00833684
Score:  0.925
Data Source:  STRINGDB
COL9A1
Tbio
Novelty:  0.0160066
Score:  0.924
Data Source:  STRINGDB
COL18A1
Tbio
Novelty:  0.00074602
Score:  0.922
Data Source:  STRINGDB
COL15A1
Tbio
Novelty:  0.04078006
Score:  0.921
Data Source:  STRINGDB
COL4A6
Tbio
Novelty:  0.02524039
Score:  0.92
Data Source:  STRINGDB
COL11A1
Tbio
Novelty:  0.00594683
Score:  0.919
Data Source:  STRINGDB
COL11A2
Tbio
Novelty:  0.00923441
Score:  0.917
Data Source:  STRINGDB
COL4A1
Tbio
Novelty:  0.00358049
Score:  0.917
Data Source:  STRINGDB
Pathways (7)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen degradation
Reactome
Collagen formation
Reactome
Degradation of the extracellular matrix
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen degradation
Collagen formation
Degradation of the extracellular matrix
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
47.7
liver fat measurement
1
1
1
31.4
wellbeing measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
47.7
liver fat measurement
1
31.4
wellbeing measurement
1
15.8
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
collagen type XIX alpha 1 chain
716948
Mouse
MGI:1095415
12823
Rat
RGD:1308920
367236
Dog
collagen type XIX alpha 1 chain
VGNC:39463
481872
Horse
collagen type XIX alpha 1 chain
VGNC:16729
100070855
Species
Name
OMA
EggNOG
Inparanoid
Macaque
collagen type XIX alpha 1 chain
Mouse
Rat
Dog
collagen type XIX alpha 1 chain
Horse
collagen type XIX alpha 1 chain
Publication Statistics
PubMed Score 8.96
PubMed score by year
PubTator Score 3.06
PubTator score by year